Browse > Article

Effects of the Extracts from Pelvetia siliquosa on Metabolism Regulation in Rats  

Lee, Sang-Hyun (College of Pharmacy, Seoul National University)
Lee, Yeon-Sil (Seokwon Life Science Research Institute, World Sea Green Co. Ltd.)
Jung, Sang-Hoon (Natural Products Research Center, KIST)
Shin, Kuk-Hyun (Seokwon Life Science Research Institute, World Sea Green Co. Ltd.)
Kim, Bak-Kwang (College of Pharmacy, Seoul National University)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.3, 2004 , pp. 203-206 More about this Journal
Abstract
Effects of the EtOH extract from Pelvetia siliquosa on $CCl_4$-induced hepatotoxicity as well as streptozotocin-induced diabetes in rats were investigated. The EtOH extract was found to cause an inhibition of the rise in the transaminase activities in $CCl_4$-intoxicated rats. Also, the EtOH extract exhibited a rat lens aldose reductase inhibition in vitro and showed an inhibition of not only glucose concentrations but also sorbitol accumulations in the lenses, red blood cells and sciatic nerves in the STZ-induced diabetic rats in vivo. These results suggested that this plant might possess hepatoprotective and anti-diabetic activities.
Keywords
Pelvetia siliquosa; Fucaceae; hepatotoxicity; diabetes;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Oh, Y S., Lee, I. K, and Boo, S. M. (1990) An annotated account of Korean economic seaweeds for food, medicinal and industrial uses. Kor. J. Phycol. 5: 57-71
2 한국식물도감 제8권 식물편(해조류) (1968) 문교부. p. 29
3 Parmar, N. S., and Ghosh, M. N. (1979) Effect of gossypin, a flavonoid, on the formation of galactose induced cataracts in rats. Exp. Eye Res. 29: 229   DOI   ScienceOn
4 Datiles, M., and Fukui, M. N. (1982) Galactose cataract prevention with sorbinil, an aldose reductase inhibitor. Invest. Opthalmol. Vis. Sci. 22: 174
5 Sestani, K., and Bellini, F. (1984) N-[(5-(trifluoromethyl)-6methoxy- l-naphthalenyl)thioxomethyl]-N-methyl-glycine, a potent, orally active aldose reductase inhibitor. J. Med. Chem. 27: 255   DOI   PUBMED
6 Yoon, J. T. (1995) Developmental morphology on the regeneration of Pelvetia siliquosa Tseng et Chang, Phaeophyta in Korea. Chungbuk National University. Ph. D. Thesis
7 공용근, 김길주, 윤장택(1998) 남해안 지역특성 해조류 양식품종 및 기술배갈 II. 뜸부기 양식기술 개발 시험, 남해수산연구소 사업보고서: pp. 242-254
8 Hayman, S. and Kinoshita, J. H. (1965) Isolation and properties of lens aldose reductase. J. BioI. Chem. 240: 877-882
9 Clements, R. S., Jr. Morrison, A. D., and Winegard, A. I. (1969) Polyol pathway in aorta: Regulation by hormones. Science 166: 1007-1008   DOI   PUBMED   ScienceOn
10 Sato, Y. and Rifkin, D. B. (1989) Inhibition of endothelial cell movement by pericytes and smooth muscle cells: Activation of a latent transformation growth factor Bl-like molecule by plasmin during coculture. J. Cell. Biol. 109: 309-315   DOI   ScienceOn
11 Williamson, J. R, Chang, K, Frangos, M., Hasan, K. S., Ido, Y, Kawamura, T., Nyengard, J. R., Van Den Enden M., Kilo C., and Tilton R. G. (1993) Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 42: 801-813   DOI   ScienceOn
12 Travis, S. F, Morrison, A. D., Clements, R. S. Jr., Winegrad, A I., and Oski, E. A. (1974) The role of the polyol pathway in metahemoglobin reduction in human red cells. Br. J. Haematol. 27: 597   DOI   ScienceOn
13 Greene, D. A, Lattimer, S. A, and Sima, A . F. (1987) Sorbitol, phosphinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications. N. Eng. J. Med. 316: 599-606   DOI   ScienceOn
14 Malone, J. I., Knox, G., Benford, S., and Tedesco, T. A (1980) Red cell sorbitol. An Indicator of diabetic control. Diabetes 29: 861   DOI   ScienceOn
15 Lee, Y and Kang, S. A (2001) Catalogue of the Seaweeds in Korea. Jeju Natural University Press. pp. 179-180
16 Gabby, K. H. (1972) Purification and immunological identification of bovine retinal aldose reductase. Isr. J. Med. Sci. 8: 1626
17 Beyer, M. A. and Farnsworth, P. N. (1979) Diminished sugar cataractogenesis by quercetin. Exp. Eye Res. 28: 709   DOI   ScienceOn
18 Seaquist, E. R, Goeta, E. C., Rich, S., and Barbosa. (1989) Familial clustering of diabetic kidney disease: Evidence for genetic susceptibility to diabetic nephropathy. N. Eng. J. Med. 320: 1161-65   DOI   ScienceOn