Browse > Article

Effects of Water and Methanol Extracts of Cricket (Gryllus bimaculatus) on Alcohol Metabolism  

Lee, Yong-Woo (Department of Agricultural biology, National Institute of Agricultural Science & Technology, RDA)
Lim, Soon-Sung (Silver Biotechnology Research Center, Hallym University)
Ryu, Kang-Sun (Department of Agricultural biology, National Institute of Agricultural Science & Technology, RDA)
Lee, Heui-Sam (Department of Agricultural biology, National Institute of Agricultural Science & Technology, RDA)
Kim, Ik-Soo (Department of Agricultural biology, National Institute of Agricultural Science & Technology, RDA)
Kim, Jin-Won (Department of Agricultural biology, National Institute of Agricultural Science & Technology, RDA)
Ahn, Mi-Young (Department of Agricultural biology, National Institute of Agricultural Science & Technology)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.2, 2004 , pp. 175-178 More about this Journal
Abstract
The cricket has been used in East Asia as crude drugs for treating fever and hypertension, and is presently reared as a pharmaceutical insect in China and a food for animals. For the purpose of evaluating protective extracts against alcohol-induced toxicity, the extracts of the cricket (Gryllus bimaculatus) were examined in animal models acutely administered alcohol by the cricket in ICR-mice. Water and methanol extracts from the cricket, were found to cause a significant decrease (37%) in the blood ethanol concentration as well as enhancement of liver mitochondrial alcohol dehydogenase (ADH) and acetaldehyde dehydogenase (ALDH) activitieson on a single intraperitoneal administration in mice. Futhermore methanol extract was demonstrated to exhibit more potent enhancing activity on ethanol metabolism than water extract. These results suggest that water/alcohol extract of G. bimaculatus may be used as a food for reducing the toxicity of alcohol.
Keywords
enhancement of ethanol metabolism; ADH; c-ALDH; m-ALDH; water extracts;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kim C. H. (1989) Insect and human. pp. 110-111. Kyungbuk University Press, Daegu
2 Sung K. C., Kang J. S., Lee C H., Koh H. C, Shin I. C., Kang S. H., Jeon Y. C., and Om A. S. (2000) The effect of gender on the gastric alcohol dehydrogense (GADH) activity in normal Sprague-Dawley Rats. J. Appl. Pharm., 8: 38-43
3 Ahn M. Y., Ryu K. S., Park B. Y., Kim D. W, Kim I., and Kim S. H. (2000) Effect of cricket on the chicken and its egg. Korean J. Poult. Sci., 27: 197-202
4 Sur J. S. (1999) Alcohol metabolism and nutritional effects, Food Industry and Nutrition, 4: 13-19
5 Mezey E., Potter J. J., Mishra L., Sharma S., and Janicot M. (1990) Effect of insulin-like growth factor 1 on rat alcohol dehydrogenase in primary hepatocyte culture, Arch. Biochem. Biophys., 280: 390-396   DOI   ScienceOn
6 Kim C. I. (1999) Cause and effect of hangover, Food Industry and Nutrition, 4: 26-30
7 Lee Y. J., Pantuck C. B., and Pantuck E. J. (1993) Effect of ginseng on plasma levels of ethanol in the rat. Planta Med, 59: 17-19   DOI   ScienceOn
8 Lee H. J. and Lee H. M. (1999) Screening of alcohol dehydrogenase inhibitors from natural products. Yakhak Hoeji, 43: 481-486
9 Shin K. H., Han Y. N., Chung H. S., Lim S. S., Lee S. H., and Shim C. S. (1998). Effects of high molecular weight fractions of Aloe spp. on alcohol metabolism. Korean J. Pharmacogn. 29: 120-124
10 Ahn M. Y., Lee Y. W., Ryu K. S., Lee H. S., Kim I, Kim J. W, Lee Y. K., Kim E. S., and Kim Y. S.,(2OO2) Protective effects of water/methanol extracts of cricket on the acute hepatic damages in the ICR-rnice induced by administration of $CC1_4$. Korean J. Food Sci. Technol. 34: 684-687