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Effect of Stilbene Derivatives from Rheum undulatum on Carrageenan-Induced Acute Edema in Rats  

Ko, Sung-Kwon (Korea Ginseng Institute, Chung-Ang University)
Shin, Cha-Gyun (Dept. of Biotechnology, Chung-Ang University)
Lee, Hak-Sung (Dept. of Biotechnology, Chung-Ang University)
Han, Sung-Tai (Dept. of Biotechnology, Chung-Ang University)
Yang, Byung-Wook (Dept. of Biotechnology, Chung-Ang University)
Im, Byung-Ok (Korea Ginseng Institute, Chung-Ang University)
Chung, Sung-Hyun (School of Pharmacy, Kyung-Hee University)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.2, 2004 , pp. 171-174 More about this Journal
Abstract
In order to examine the anti-ohyul (anti-inflammatory) activity of rhubarb, we investigated the effects of stilbene derivatives obtained from rhizomes of Rheum undulatum on the carrageenan-induced hind paw edema in rats. Administration of stilbene aglycon (rhapontigenin) at doses of 50 and 100 mg/kg exhibited the anti- edema effect in dose dependent manner and stilbene glycosides $(rhaponticin,\;piceatannol-3 at a dose of 100 mg/kg also showed inhibitory effect on the carrageenan-induced edema. These inhibitory effects may ascribed, at least in part, to the anti-ohyul activity of rhubarb.
Keywords
Carrageenan; Rheum undulatum; stilbene derivatives; rhapontigenin; rhaponticin; $piceatannol-3;
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