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Anti-Proliferative Activity of Naturally Occurring Flavonoids on Cultured Human Tumor Cell Lines  

Kim, Jung-Sook (Korea Research Institute of Chemical Technology)
Choi, Yeon-Hee (Korea Research Institute of Chemical Technology)
Seo, Jee-Hee (Korea Research Institute of Chemical Technology)
Lee, Jung-Won (Korea Research Institute of Chemical Technology)
Kim, Seong-Kie (Korea Research Institute of Chemical Technology)
Choi, Sang-Un (Korea Research Institute of Chemical Technology)
Kang, Jong-Seong (College of Pharmacy, Chungnam National University)
Kim, Young-Kyoon (College of Forest Science, Kookmin University)
Kim, Sung-Hoon (Graduate School of East-West Medical Science, Kyunghee University)
Kim, Young-Sup (Korea Research Institute of Chemical Technology)
Ryu, Shi-Yong (Korea Research Institute of Chemical Technology)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.2, 2004 , pp. 164-170 More about this Journal
Abstract
The flavonoids are a very large and important group of polyphenolic natural products, which are united by their derivatization from the heterocycle, flavone. They are distributed in higher plants and occur widely in the fruits and vegetables that make up the human diet. They exhibit a wide range of biological properties, including antitumor, antiinflammatory, hepatoprotective, antimicrobial, insecticidal and estrogenic activities. They are also major components of many plant drugs and it is possible that they contribute to the curative properties. For the purpose of developing anticancer agent of natural origin, we have evaluated forty four kinds of naturally occurring flavonoids for the inhibitory activity upon the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon) in vitro.
Keywords
Flavonoid; antitumour; human tumour cells; SRB method;
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