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Isolation of Melanin Biosynthesis Inhibitory Compounds from the Flowers of Magnolia denudata  

Xu, Guang-Hua (College of Pharmacy, Yeungnam University)
Kim, Jeong-Ah (College of Pharmacy, Yeungnam University)
Park, Sung-Hee (College of Pharmacy, Yeungnam University)
Son, Ae-Ryang (College of Pharmacy, Yeungnam University)
Chang, Tae-Soo (Department of Cosmetics, Sorabol College)
Chang, Hyun-Wook (College of Pharmacy, Yeungnam University)
Chung, See-Ryun (College of Pharmacy, Yeungnam University)
Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.2, 2004 , pp. 152-156 More about this Journal
Abstract
The bioassay-guided fractionation of the MeOH extract of the flowers of Magnolia denudata led us to the isolation of six compounds identified as fargesin(1), kobusin(2), aschantin(3), magnolin(4), rel-[7s,8s,8's]-3,4,3',4'-tetra- methoxy-9,7'- dihydroxy-8,8',7.O.9'-lignan(5) and oplodiol(6), respectively. Among the isolated compounds, fargesin(1) showed most potent inhibitory effect on the melanin polymer biosynthesis in cultured B-16 mouse melanoma cell lines$(IC_{50},\;45.7\;{\mu}M)$.
Keywords
Magnolia denudata; melanogenesis inhibitor; lignan; fragesin;
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