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Protective Effect of MeOH Extract of Evodia officinalis on Cyanide-induced Neurotoxicity in Cultured Neuroblastoma Cells  

Kim, Sang-Tae (Juam of Research Institute Bioscience & Biotechnology,College of Forest Science, Kookmin University)
Ahn, Soung-Hee (Juam of Research Institute Bioscience & Biotechnology,College of Forest Science, Kookmin University)
Kim, Jeong-Do (Juam of Research Institute Bioscience & Biotechnology,College of Forest Science, Kookmin University)
Kim, Young-Kyoon (Juam of Research Institute Bioscience & Biotechnology,College of Forest Science, Kookmin University)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.4, 2003 , pp. 282-287 More about this Journal
Abstract
We reported that neurotoxicity may contribute to cyanide-induced neuronal injury. Cyanide stimulates the release of glutamate which can activate glutamate receptors to propagate excitotoxic processes. We examined the role of plant extracts in mediating the cyanide-induced cytotoxicity and report here that the cytotoxicity assessed in SK- N-SH cell cultures by measuring lactate dehydrogenase (LDH) in the culture media was significantly blocked by Evodia officinalis MeOH extract (OMU). Also, when OMU was treated in NaCN level cultures, the neurite outgrowth was regenerated as much as in the treatment of NaCN only. These results indicate that OMU treatment were not only protected the neurons against NaCN-induced damage but also regenerated the neurite outgrowth of neuroblastoma cells.
Keywords
Cytotoxicity; LDH; NaCN; apoptosis; neurite outgrowth; Evodia officinalis;
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