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Induction of Growth Hormone Release by the Extracts of Lonicera japonica $T_{HUNB.}$  

Jung, Dae-Young (Department of Herbal Medicine, Korea Institute of Oriental Medicine)
Lee, Ho-Young (Department of Herbal Medicine, Korea Institute of Oriental Medicine)
Ha, Hye-Kyung (Department of Herbal Medicine, Korea Institute of Oriental Medicine)
Jung, Da-Young (Department of Herbal Medicine, Korea Institute of Oriental Medicine)
Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
Kim, Chung-Sook (Department of Herbal Medicine, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.3, 2003 , pp. 256-262 More about this Journal
Abstract
Lonicerae Flos (LF) has been used as an anticancer, anti-viral, and anti-inflammatory agent in traditional herbal medicine. In this study, induction of rat growth hormone (rGH) by addition of methanol (MeOH) extract of LF of Lonicerae (L.) Folium or several constituents of L. Folium were carried out in the pituitary cell culture system. Induced rGH level by addition of 70% MeOH extract of LF was increased to $732.65{\pm}105.64%$ of control (n=18, p<0.01), however, the other sequential fractions were not significantly different from the control. Ochnaflavone, a constituent of L. Folium, induced rGH level in the cell culture to $329.73{\pm}160.00%$ of control (n=6, p<0.01). An I..v. injection of the MeOH extract of LF did not increase plasma rGH level in anesthetized rats. Unfortunately, the MeOH extract of LF induced prolactin and LH release about 7 and 5 fold of the control, respectively (p<0.05, each). In conclusions, 70% MeOH extract of LF exerted induction of rGH release in rat pituitary cell culture. Further studies to investigate mechanisms of the inducded rGH by LF are in progress.
Keywords
Lonicerae Flos; Lonicerae Folium; rat growth hormone; pituitary cell culture; ochnaflavone;
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