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Hepatoprotective Effects of Water Extract of Liriopis Tuber on Carbon Tetrachloride-Induced Hepatotoxicity in Rats  

An, Ji-Yoon (College of Pharmacy, Catholic University of Daegu)
Rhee, In-Ja (College of Pharmacy, Catholic University of Daegu)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.2, 2003 , pp. 166-171 More about this Journal
Abstract
The hepatoprotective effects of Liriopis tuber on carbon tetrachloride $(CCl_4)$ intoxicated rats were studied. The water extract prepared from Liriopis tuber were administrated to the pretreatment group orally once a day for successive 7 days, followed by treatment with $CCl_4$ on the seventh day. The post treatment group was treated with $CCl_4$ and then the water extract was administrated. The activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LDH), and contents of total cholesterol and triglyceride in pretreatment rats serum were significantly decreased compared to the only $CCl_4$ treated rats. The level of high density lipoprotein (HDL) cholesterol was considerably increased compared to the only $CCl_4$ treated rats. In the pretreatment group with the water extract of Liriopis tuber tissue destruction was not observed in light microscopic investigation, compared to the only $CCl_4$ treated rats. These results suggest that Liriopis tuber have potent hepatoprotective effect against carbon tetrachloride intoxicated rats.
Keywords
Hepatoprotective effect; Carbon tetrachloride; Liriopis tuber;
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