Browse > Article

Studies on the Crude Drugs of Atractylodis Species  

Kim, Ho-Hyun (College of pharmacy Chung-Ang University)
Chon, In-Ju (College of pharmacy Chung-Ang University)
Kang, In-Ho (College of pharmacy Chung-Ang University)
Ham, In-Hye (College of pharmacy Chung-Ang University)
Ze, Keam-Ryon (College of pharmacy Chung-Ang University)
Whang, Wan-Kyunn (College of pharmacy Chung-Ang University)
Cho, Hyoung-Kwon (Korean Food and Drug Administration)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.2, 2003 , pp. 123-127 More about this Journal
Abstract
Atrartylodis Rhizoma(蒼朮)'s origin plants are Atratylodes lancea and A. Chinensis in Chinese, Japanese and Korean pharmacopoeia. A. Japonica is only indigenous in Korea, it is actually used as Atractylodis Rhizoma in Korean market. A. lancea is used in Hunan province, China and A. Chinensis is used in Hubei province, China. It is impossible to distinguish with species differency as macro- and micro-morphology. We tried to distinguish with species differency by HPLC and GC-Mass spectra. Atractylone(mw. 216) which is a marker compound in Atractylodis Rhizoma Alba(白朮) was detected in A. japonica. Atractylodin (mw.182) was detected in A. lancea and two eudesmadien derivatives (mw. 204) were detected in A. chinensis. HPLC chromatogram showed the same patterns. As a result, we propose that A. japonica will be added as Atractylodis Rhizoma (蒼朮)'s origin plant in Korean Pharmacopoeia. Atractylodis Rhizoma Alba(白朮)'s origin plants are A. macrocephala in China, and A. Japonica and A. ovata in Korea and Japan. In GC-Mass analysis, all samples showed same patterns and the main compound was atractylone.
Keywords
Atractylodis Rhizoma; Atractylodis Rhizoma Alba; Compositae; atractylone; GC-Mass; HPLC;
Citations & Related Records
연도 인용수 순위
  • Reference
1 일본약국방 제 13 개정 (1996), D-674, D-980, D-98, 광천서점, 일본
2 Keiichi Suto (1998) Determination of atractylon in Atractylodes rhizoma using supercritical fluid chromatography online coupled with supercritical fluid extraction by the direct induction method. Joumal of Chromatography A. 810: 252255   DOI   ScienceOn
3 元道喜, 쭈海彬, 趙쫀衝, 洪南斗, 張承嬅, 趙貞繆, 金惠決, 成樂宣(1991)常用生藥의 成分定量. 231-235. 聖恩. 서울
4 대한약전 제 7 개정 (1997) 일반시험법 1345: 1369
5 한약(생약)규격집 (200) 446: 197, 198. 한국의약품수출입협회 한국의약품시험연구소
6 Pharmacopoeia of the People's Republic of CHINA (1997) 1:183, 184. Chemical industry press, 베이징
7 육창수(1993) 원색한국약용식물도감, 531: 아카데미서적, 서울
8 新編 中藥大辭典(中華民國 71率), 2369-2373. 新丈豊出 公司, 臺北布.
9 Noriko Yasuda (1996) Study of Components Crude drugs by Headspace Gas Chromatography. II. components of Atractylodes 業學雜誌. 116: 728-734
10 육창수(1997) 아세아 생약도감, 520: 경원, 서울