Browse > Article

Hypoglycemic Activity of Opuntia ficus-indica var.sabotan on Alloxan- or Streptozotocin-Induced Diabetic Mice  

Shin, Ji-Eun (Department of Food and Nutrition, Kyung Hee University)
Han, Myung-Joo (Department of Food and Nutrition, Kyung Hee University)
Lee, In-Kyung (Korea Seogwipodasin Middle School)
Moon, Young-In (Bukjeju County Rural Community Guidance Center)
Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.1, 2003 , pp. 75-79 More about this Journal
Abstract
Hypoglycemic activity of Opuntia ficus-indica var. sabotan on alloxan or streptozotocin-induced diabetic mice was investigated. Fructus and folium of Opuntia ficus-indica vars. sabotan inhibited intestinal ${\alpha}-glucosidase$ of rats as well as glucose elevation in blood of normal mice, Opuntia ficus-indica var. sabotan exhibited inhibitory activities on streptozotocin-induced diabetic mice rather than on alloxan-induced diabetic mice loaded with maltose and sucrose. Its folium was more effective than its fructus. These results suggest that Opuntia ficus-indica var. sabotan might be effective on diabetic mellitus.
Keywords
Opuntia ficus-indica var. sabotan; ${\alpha}-glucosidase$ inhibition; hypoglycemic activity; diabetic mice;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Lee, Y.C., Hwang, K.H., Han, D.H. and Kim, S.D. (1997) Compositions of Opuntia ficus-indica. Kor. J Food Sci. Technol. 29(5): 847-853
2 Kimura, M., Chen, F.J., Nakashima, N., Kimura, I., Asano, N. and Koya, S. (1995) Antihyperglycemic effects of Ncontaining sugars derived from Mulberry leaves in streptozotocininduced diabetic mice. J. Traditional Medicines. 12: 214-219
3 Malaisse, W. J, Malaisse-Lagae, F., Sener,A and Pipeleers, D.G. (1982) Determinants of the selective toxicity of alloxan on the pancreatic $\beta$-cell. Proc. Natl. Aoad. Sci. 79: 927-930   DOI   ScienceOn
4 Lee, S.P., Whang, K and Ha, Y.D. (1998) Functional properties of mucilage and pigment extracted from Opuntia Ficus-indica. Kor. Soc. Food Sci. Nutr. 7: 822-826
5 Nam, M.S., Kim, K.R., Cho, J.H., Lee, K.M., Park, H.Y., Lee, E.J., Lim, S.K., Lee, H.C. and Huh, KB. (1994) A study on the folk remedies by the questionnaries in Korean diabetic patients. Diabetes. 18(3): 242-248
6 Ahmed, A.E., Smithard, R. and Ellis, M. (1991) Activities of enzymes of the pancrease, and the lumen and mucosa of the small intestine in growing broiler cockerels fed on tannincontaining diets. Br. J. Nutr. 65: 189-197   DOI   ScienceOn
7 Kim, I.H., Kim, M.H., Kim, H.M. and Kim, Y.E. (1995) Effect of antioxidants on the thermostability of red pigment in prickly pear. Kor. J. Food Sci. Thechnol. 27: 1013-1016
8 http://members.tripod.co.kr/orange72/sub-2.
9 Noel, D.V. (1986) Lesser-known plants of potential use in agriculture and forestry. Science. 232: 1379   DOI   ScienceOn
10 Chung, M.S. and Kim, KH. (1996) Stability of betanine extracted from Opuntia Ficus-indica var. Saboten. Kor. J Soc. Food Sci. 12: 506-510
11 Hikino, H., Mizuno, T., Oshima, Y. and Konno, C. (1985) Isolation. and hypoglycemic acticity of Moran A, a glycoprotein of Moms Alba Root Barks. Planta Medica. 159-162
12 Shin, J.E., Han, M.J., Lee, Y.C,, Moon, Y.I. and Kim, D.H. (2002) Antidiabeticactivity of Opuntia ficus-indica var. sabotan on db/db mice. Kor. J. Pharmacol., 33(4): 332-336
13 Axelrad, A.D., Lawrence, A.L. and Hazelwood, R.L. (1970) Fasting and alloxan diabetes effects on intestinal transport of monosaccharides. Am J. Physiol. 21 : 860-864
14 http://www.bukjeju.agri.cheju.kr/totallgoodiOOl.htm
15 Sawaya, W.N. and Khatchandourian, H.A. (1983) Chemical characterizationof prickly pear, Opuntia ficus-indica, and the manufacturing of pricly peart jam. Presented at the 68th Annual meeting of the intemational of milk, food & enviroment sanitarians, Inc. Spokane, WA, Aug. 9012