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Tyrosinase Inhibitors isolated from the Roots of Glycyrrhiza glabra L.  

Lee, Joo-Sang (College of Pharmacy, Yeungnam University)
Kim, Jeong-Ah (College of Pharmacy, Yeungnam University)
Cho, Se-Hoon (College of Pharmacy, Yeungnam University)
Son, Ae-Ryang (College of Pharmacy, Yeungnam University)
Jang, Tae-Soo (Department of Cosmetics, Sorabol College)
So, Myung-Suk (Department of Nursing, Daegu Health College)
Chung, See-Ryun (College of Pharmacy, Yeungnam University)
Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.1, 2003 , pp. 33-39 More about this Journal
Abstract
Eight compounds were isolated from the roots of Glycyrrhiza glabra by the tyrosinase inhibitory activity guided fractionation, and their structures were identified as liquiritigenin (1), isoliquiritigenin (2), isoliquiritigenin-2'-O-methyl ether (3), liquiritin (4), isoliquiritin (5), ononin (6), glycycoumarin (7), glycyrol (8) by analysis of spectral data. Compound 3 exhibited the most potent inhibitory effect on mushroom tyrosinase activity ($IC_{50}$, 47 M).
Keywords
Glycyrrhiza glabra; tyrosinase; melanin polymer; flavonoid; isoliquiritigenin-2`-O-methyl ether;
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