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Inhibitory Effects of Stilbene Derivatives from Rheum undulatum on Cyclooxygenase Activity  

Lee, Chung-Ryul (Korea Ginseng Institute, Chung-Ang University)
Lee, Hak-Sung (Korea Ginseng Institute, Chung-Ang University)
Kim, Hyun (Korea Ginseng Institute, Chung-Ang University)
Baek, Koo-Hyun (Korea Ginseng Institute, Chung-Ang University)
Tokuoka, Kiyoshi (Dainippon Pharmaceutical CO., LTD.)
Chung, Sung-Hyun (School of Pharmacy, Kyung-Hee University)
Ko, Sung-Kwon (Korea Ginseng Institute, Chung-Ang University)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.1, 2003 , pp. 25-27 More about this Journal
Abstract
In order to clarify the anti-thrombosis activity of rhubarb, we investigated the effect of stilbene derivatives from rhizomes of Rheum undulatun on cyclooxygenase activity. Stilbene derivatives (desoxyrhapontigenin, rhapontigenin, piceatannol) exhibited the inhibitory effects on COX-1, and desoxyrhapontigenin showed inhibitory effect on COX-2. These inhibitory effect may partially contributed to anti-thrombosis activity of rhubarb.
Keywords
Cyclooxygenase; Rheum undulatum; stilbene derivatives; desoxyrhapontigenin; rhapontigenin; piceatannol;
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