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An Acetylcholinesterase Inhibitor from the Leaves of Securinega suffruticosa  

Jang, Choon-Hee (College of Pharmacy, Woosuk University)
Eun, Jae-Soon (College of Pharmacy, Woosuk University)
Park, Hye-Won (College of Pharmacy, Woosuk University)
Seo, Seon-Mi (College of Pharmacy, Woosuk University)
Yang, Jae-Heon (College of Pharmacy, Woosuk University)
Leem, Kang-Hyun (College of Pharmacy, Woosuk University)
Oh, Seok-Heung (College of Science and Technology, Woosuk University)
Oh, Chan-Ho (College of Science and Technology, Woosuk University)
Baek, Nam-In (Department of Life Science, Kyung-Hee University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.1, 2003 , pp. 14-17 More about this Journal
Abstract
In the course of screening Korean natural plants for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the leaves of Securinega suffruticosa showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of dihydrosecurinine, as a active principle. This compound inhibited AChE activity in a dose-dependent manner, and the $IC_{50}$ value of dihydrosecurinine was $18.9\;{\mu}g$.
Keywords
Securinega suffruticosa; acetylcholinesterase; dihydrosecurinine;
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