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Screening of Arachidonic acid Cascade Related Enzymes Inhibitors from Korean Indigenous Plants(1)  

Moon, Tae-Chul (College of Pharmacy, Yeungnam University)
Jung, Hye-Jin (College of Pharmacy, Yeungnam University)
Lee, Eun-Kyung (College of Pharmacy, Yeungnam University)
Park, Hae-Young (Depart. Food & Nutrition, Andong National University)
Jeon, Su-Jin (Depart. Food & Nutrition, Andong National University)
Son, Kun-Ho (Depart. Food & Nutrition, Andong National University)
Kim, Hyun-Pyo (College of Pharmacy, Kangwan National University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Kang, Sam-Sik (Natural Products Res. Institute. Seoul National University)
Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy and Korea Institute of Oriental Pharmacy, Wonkwang University)
Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.1, 2003 , pp. 109-117 More about this Journal
Abstract
Arachidonic acid(AA), which is stored in membrane glycerophospholipids, is liberated by phospholipase $A_2(PLA_2)$ enzymes and is sequentially converted to cyclooxygenase (COX) and lipoxygenase (LOX) then to various bioactive prostaglandins (PGs,) and leukotrienes (LTs). In order to find the specific inhibitors of AA metabolism enzymes such as $PLA_2$, COX-2, 5-LO and lyso PAF acetyltransferase. 195 Korean indigenous plant extracts were evaluated for their inhibitory activity on $PGD_2,\;LTC_4$ production from cytokine-induced mouse bone marrow-derived mast cells (BMMC) and arachidonic acid released from phospholipid and PAF production from lyso PAF. From this screening procedure, methanol extract of eight plants such as Saururus chinensis, Aster tataricus, Chrysanthemum cinerariaefolium, Reynoutria japonica, Disocorea nipponica, Epimedium koreanum, impatiens textori, Veronica rotunda var. subintegra were found to inhibit production of inflammatory mediators in vitro assay system.
Keywords
Secretory phospholiase $A_2$; cyclooxygenase-2; 5-lipoxygenase; lyso PAF acetyltransferase; inhibitors; korean indigenous plants; anti-inflammatory agents;
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1 Vadas, P., Pruzanski, P. (1986) Biology of diseases. Role of secretory phospholipase $A_2$ in the pathobiology of diseases. Lab. Invest. 55: 391-404
2 Kraemer, S.A, Meadde, E.A and DeWitt, D.L. (1992) Prostaglandin endoperoxide synthase gene structureidentification of the transcriptional start site and 5'-flanking regulatory sequences. Arch. Biochem. Bio. Phys. 293: 391-400   DOI   ScienceOn
3 Yanoshita R., Chang n.w, Son K.H., Kudo I. and Samejima Y (1996) Inhibition of lyso-PAF acetyltransferase activity by flavonoids. Inflammation Res. 45: 546-549   DOI   ScienceOn
4 Moon, T.C., Chung, K.W., Chung, K.C, Son, K.H., Kim, H.P., Kang, S.S., and Chang, H.W. (1997) Screening of inflammatory phospholipase $A_2$ inhibitors from natural products 41(5): 565-570
5 Dole, V.P. and Meinertz, H. (1960) Microdetermination of long-chain fatty acids in plasma and tissue. J. Biol. Chem. 235: 2595-2599
6 Murakami, M., Matsumoto, R., Urade, Y., Austen, K.F., and Arm, J.P. (1995) c-Kit ligand mediates increased expression of cytosolic phopholipase $A_2,$ prostaglandin endoperoxide synthase-I, and hematopoietic prostaglandin $D_2$ synthesis and increased IgE-dependent prostaglandin $D_2$ generation in immature mouse mast cells. J. Biological Chem. 270: 32393246   DOI   ScienceOn
7 Morita, I., Schindler, M., Regier, M.K., Otto, J.C., Hori, T., DeWitt, D.L. and Smith, W.L. (1995) Different intracellular location for prostaglandin H synthase-l and synthase-2. J. BioI. Chem. 270: 10902-10908   DOI   ScienceOn
8 Forster, S., Ilderton, E., Norris, JFB. and Yardley, H. J. (1985) Characterization and activity of phospholipase $A_2$ in normal human epidermis and in lesion-free epidermis of patients with psoriasis or eczema. Br. J. Dermatol. 112: 135-147   DOI   ScienceOn
9 Pilbram, C.C., Kawaguchi, H., Hakeda, Y., Voznesensky, O., Alander, C. B. and Raisz, L.G (1993) Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic Me 3T3-El cells. J. BioI. Chem. 268: 25643-25649
10 Chang, H. W., Kudo, I., Hara, S. and Inoue, K. (1986) Extracellular phospholipase A$A_2$ activity in peritoneal cavity of casein-treated rats. J. Biochem. 100: 1099-1101
11 Ishizaki, J., Suzuki, N., Higashino, K, Yokota, Y., Ono, T, Kawamoto, K, Fujii, N., Arita, H. and Hanasaki, K (1999) Cloning and characterization of novel mouse and human secretory phospholipase $A(_2)s.$ J. Biol. Chem. 274: 24973-24979   DOI   PUBMED
12 Chang, H. W., Baek, S. H., Chung, K. W., Son, K. H., Kim, H. P. and Kang, S. S. (1994) Inactivation of phospholipase $A_2$ by naturally occuring biflavonoid, ochnaflavone. Biochem. Biophys. Res. Commun. 205: 843-849   DOI   ScienceOn
13 Moon, T.C., Murakami. M., Kudo, I., Son, K.H., Kim, H.P. and Chang H.W. (1999) A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa. Inflammation Res. 48: 621-635   DOI   ScienceOn
14 Doebber, T. W., Wu, M.S., Robbins, J.C., Choy, B. M., Chang, M. N. and Shen, T. Y. (1986) Platelet activating factor(PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptors antagonist Kadsurenone. Biochem. Biophys. Res. Commun. 127: 799-808   DOI   ScienceOn
15 Pritchard Jr.K.A., O'Banion, M.K., Miano, J.M., Vlasic, N., Bhatia, U.G., Young, D.A. and Stemerman, M.B. (1994) Induction of cyclooxygenase-2 in rat vascular smooth-muscle cells in-vitro and in-vivo., J. Biol. Chem. 269: 8504-8509.
16 Valentin E., Koduri R.S., Scimeca J.C., Carle G., Gelb M.H., Lazdunski M. and Lambeau G. (1999) Cloning and recombinant expression of a novel mouse-secreted phospholipase Az. J. Biol. Chem. 274: 19152-19160   DOI   PUBMED
17 Murakami, M., Bingham, C.O., Matsumoto, R., Austen, K.F., and Arm, J.P. (1995) IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin $D_2$ generation via prostaglandin endoperoxidase synthase-2. J. Immunol. 155: 4445-4453
18 Moon, T.C., Chung, K.C., Son, K.H., Kim, H.P., Kang, S.S., and Chang, H.W. (1998) Screening of cyclooxygenase-2 inhibitors from natural products. 42(2): 214-219.
19 Hara, S., Kudo, I., Chang, H. W. and Inoue, K (1989) Purification and characterization of extracellular phospholipase $A_2$ from human synivial fluid in rheumatoid arthritis .J. Biochem. 105: 395-399
20 Morley, J., Page, C. P., Mazzoni, L. and Sanjar, S. (1986) Effect of ketotifen upon responses to platelet activating factor: A basic for asthma prophylaxis. Annals ofAllergy, 56: 335-349
21 Reddy, S.T. and Herschman, H.R. (1994) Ligand induced prostaglandin synthesis requires expression of the TislO/Pgs2 prostaglandin synthase gene in murine fibroblast and macrophages. J. BioI. Chem. 269: 15473-15480