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Antigastritic and Anti-ulcerative Effect of P020701  

Hyun, Jin-Ee (College of Pharmacy, Duksung Women's University)
Kang, Min-Hee (College of Pharmacy, Duksung Women's University)
Kim, Hyun-Pyo (College of Pharmacy, Duksung Women's University)
Park, Ji-Man (College of Pharmacy, Duksung Women's University)
Lee, Sang-Yun (R&D center, Pulmuone Tech. Co. LTD.)
Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.4, 2002 , pp. 389-394 More about this Journal
Abstract
Present study was carried out for development of a new supplementary product with gastroprotective effect. Natural Products mentioned that have GI protective property in Dongeuibogam and reports were evaluated anti-bacterial activity against Helicobacter pylori, then five heres were selected. The material used for the test were water extract of Alpinia oxyphlla (AO), Astragalus membranaceus (AM), Cinnamomum loureirii(CL), Citrus aurantium(CA), Amomum villosum(AV). They were tested individually on HCI ethanol-induced gastric lesion in rats, AV CL, AO showed the most significant effectiveness, respectively. Then two mixture different in their content ratio (P020701-1,-2) and complex with P020701-1 (CP) were made, and tested on HCI·ethanol, indomethacin-induced gastric lesion, aspirin-ligature, Shay ulcer and gastric secretion. P020701-1, -2 and CP showed significant effect on HCI ethanol, indomethacin-induced gastric lesion, and Shay ulcer. It can be regarded that the antigasuitic and anti-ulcerative effects of P020701- 1, -2 and CP are originated from reduction of total acid output identified by gastric secretion test.
Keywords
P020701-1-2; complex with P020701-1; antigastritic; anti-ulcerative;
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