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Inhibitory Effects of Some Herbal Extracts on the Acetylcholinesterase (AChE) In Vitro  

Kim, Jeoung-Seob (Korea Research Institute of Chemical Technology)
Kim, Young-Sup (Korea Research Institute of Chemical Technology)
Kim, Seong-Kie (Korea Research Institute of Chemical Technology)
Heor, Jung-Hee (Korea Research Institute of Chemical Technology)
Lee, Bong-Ho (Department of Chemical Technology, Hanbat National University)
Choi, Byoung-Wook (Department of Chemical Technology, Hanbat National University)
Ryu, Geon-Seek (Department of Chemical Technology, Hanbat National University)
Park, Eun-Kyung (Korea Research Institute of Chemical Technology)
Zee, Ok-Pyo (College of Pharmacy, Sungkyunkwan University)
Ryu, Shi-Yong (Korea Research Institute of Chemical Technology)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.3, 2002 , pp. 211-218 More about this Journal
Abstract
The methanol extracts of 340 kinds of Korean medicinal herbs were examined in vitro for the inhibitory effect on the acetylcholinesterase (AChE, E.C. 3.1.1.7) from electric eel using acetylthiocholine as a substrate. Among tested, the extracts of Coptidis Rhizoma, Phellodendri Cortex, Evodiae Fructus, Myrrha, Arecae Semen and Piperis nigri Fructus were found to exhibit a significant inhibition upon the acetylcholinesterase in a dose dependent manner, respectively.
Keywords
acetylcholine; acetylcholinesterase; inhibition; medicinal herb; Coptidis Rhizoma;
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