Browse > Article

Effects of Polygonatum odoratum on Mercuric Chloride Induced Renal Failure Rats  

Kim, Ju-Hyang (College of Pharmacy, Sookmyung Women's University)
Yang, Ki-Sook (College of Pharmacy, Sookmyung Women's University)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.3, 2002 , pp. 200-206 More about this Journal
Abstract
The rhizoma of Polygonatum odoratum (Liliaceae) has been used as the treatment of body fluid deficiency, dryness symptoms and hyper glycemia. To study effects on acute renal failure of P. odorati rhizoma, urinary volume, urinary electrolytes and serum factors associated with renal dysfunction were measured in $HgCl_2-induced$ acute renal failure rats. It was revealed that its ether ex. had significant diuretic effects, regulated hypoelectrolytes$(Na^+,\;K^+,\;Cl^-)$ and inhibited the increase of creatinine, BUN in acute renal failure rats. From the ether ex. which was more effective than MeOH ex., three lipophilic compounds were isolated and elucidated hydrocarbon(l), ${\beta}-sitosteryl$ stearate(2), ${\beta}-sitosterol$(3). The ${\beta}-sitosteryl$ stearate(2) were isolated from Polygonatum sp. at first.
Keywords
Polygonatum odoratum; $HgCl_2-induced$ acute renal failure rats; ${\beta}-sitosteryl$ stearate;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Tsuchiya, K., Nakauchi, M., Hondo, I. and Nihei, H. (1995) Nephropathy associated with electrolyte disorders. Nippon Rinsho-Japanese J. Clin. Med. 53(8): 1995-2000
2 김태정(1996)韓國의 資濕愼物, 172. 서울대학교출판부, 서울
3 배기환(2000) 한국의 약용식물, 538. 교학사, 서울
4 Lin, H. W., Han, G. Y. and Liao, S. X. (1994) Studies on the active constituents of the Chinese traditional medicine Polygonatum odoratum Druce. Acta Pharm. Sin. 29: 215-222
5 Sugiyama, M., Nakano, K., Tomimatsu, T. and Nohaia, T. (1984) Five Steroidal Components from the Rhizomes of PoIygonatwn odoratum var. pturiftorum. Chem. Pharm. Bull. 32(4): 1365-1372   DOI
6 이규녕, 김진규(1988) 임상화학, 201. 의학문화사, 서울
7 柴田進(1970) 臨床化學의 實技, 326. 金原出版社, 서울
8 Ulubelen, A., Tan, N. and Topcu, G. (1997) Terpenoids from Salvia candidissima subsp. candidissima. Phytochem. 45(6):1221-1223   DOI   ScienceOn
9 Morita, N., Arisawa, M. and Yoshikawa, A. (1976) Studieson Medical Resources. XXXVⅢ. Studies on constituents of Polygonatum Plants (Liliaceae).(l). The constituents in the Leaves of Polygonatum odoratum ($M_{ILL}$.) $D_{RUCE}$ var. pluri-florum ($M_{IG}$.) $O_{HWI.}$Yakugaku Zasshi 96(10): 1180-1183   DOI
10 이창규(1994) 최신 임상화학, 229. 대학서림, 서울
11 鈴木, 良雄, 伊籐, 韓雄, 高村, 俊史(1982) 新利尿劑 Azo-semide [5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phnyltet-razole] の利尿作用 に關する藥理學時の究(第3報) $HgCl_2$によるラントの急注辯不全に對す る Angiotensin I 變換靜素 阻害劑 SA-446 あるいは $\beta$-遮斷劑 propranolol 前處理による Azosemideの勤果. 日藥理誌 80:395-404
12 우원식(1996) 천연물화학 연구법, 282. 서울대학교 출판부, 서울
13 Pouchert, C. J. and Behnke, J. (1993) The Aldhch Library of $^{13}C$ and $^{1}H$ FT NMR Spectra, Edition I., Aldrich Chemical Company, Inc.
14 Tsuneo Namba (1993) The Encyclopedia of Wakan-Yaku, 64. Hoikusha, Japan
15 CIark, W. G., Brater, D. C. and Johnson, A. R. (1992) Goth's Medical Pharmacology, 475-478. Mosby-Year Book, Inc., USA
16 Goad, L. J. and Akihisa, T. (1997) Analysis of Sterols, 70. Blackie Academic Professional, London
17 조영경, 이명환, 강현모, 이한구, 강삼식(1992) 골담초근의 Lipid성분에 관한 연구. 생약학회지 23(1): 14-19
18 박승아, 김태희, 양기숙(2000) 영계출감탕의 신기능에 미치는 영향. 생약학회지 31(3): 364-372
19 Natochin, Y. V, Bakhteeva, V. T. and Karpenko, L. A. (1994) Renal failure and nephrotoxic drug-induced disturbances in rat kidney tissue. Ren. Fail. 16(6): 687-696   DOI   ScienceOn
20 Mitch, W. E., Walsel, M., Steinman, T. I., Hill, S., Zeger, S. and Tungsanga, K. (1984) The effect of a keto acid-amino acid supplement to a restricted diet on the progression of chronic renal failure. N. Enst. J. Med. 311(10): 623-629   DOI   ScienceOn
21 Milt, T., Ishani, A., Mac Donald, R., Stark, G., Mulrow, C. and Lau, J. (2000) $\beta$-sitosterols improve urinary symptoms in the short term in men with benign prostatic hyperplasia. ACP Journal Club 132(3): 94
22 柳永辯, 姜三植, 金昌端(1990) 연밥피나무의 성분에 관한연구. 생약학회지 21(4):265-269
23 Miura, T. and Kato, A. (1995) The Difference in hypogly-cemic action between Polygonati Rhizoma and Polygonati offidnalis Rhizoma. Biol. Pharm. Bull. 18: 1605-1606   DOI   ScienceOn
24 Biber, T. U. L., Mylle, M., Baines, A. D., Gottschalk, C. W., Oliver, J. R., and MacDowell, M. C. (1968) A study in micropuncture and microdissection of acute renal damage in rats. Am. J. Med. 44(5): 664-705   DOI   ScienceOn
25 Ganote, C. E., Reimer, K. A., and Jennings, R. B. (1974) Acute mercunc chloride nephrotoxicity; An electron micro- scopic and metabolic study. Lab. Invest. 31(6): 633-647
26 김태희, 양기숙, 정연경(1985) 명아주의 이뇨작용이 Furo-semide의 작용에 미치는 영향. 생약학회지 16(3): 165-170
27 Chang, I. M., Yun, H. S. and Yamasaki, K. (1981) Revisionof $^{13}C $ NMR Assignments of $\beta$-Sitosterol and $\beta$-Sitostery1-3-O-$\beta$-D-glucopyranoside Isolated from Ptantago asiatica Seed. Kor. J. Pharmacogn. 12(1): 12-24
28 Kato, A., and Miura, T (1994) Hypoglycemic action of the rhizomes of Polygonatum officinale in normal and diabeticmice. Planta Med. 60: 201-203   DOI   ScienceOn
29 Shan S. V. (1983) Role of reactive oxygen metabolites in experimental glomerular disease. Kidney Int. 35(5): 1093-1106   DOI   PUBMED   ScienceOn
30 李琬夏(1981) 둥굴레의 血糖降下作用에 대하여. 科學技術硏究 9: 1-3