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Inhibitory Activity of Plant Extracts on Matrix Metalloproteinase-2  

Lee, Sang-Myung (Korea Research Institute of Bioscience and Biotechnology)
Chun, Hyo-Kon (Korea Research Institute of Bioscience and Biotechnology)
Lee, Ho-Jae (Korea Research Institute of Bioscience and Biotechnology)
Lee, Choong-Hwan (Korea Research Institute of Bioscience and Biotechnology)
Kim, Jin-Hee (Korea Research Institute of Bioscience and Biotechnology)
Kho, Yung-Hee (Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.2, 2002 , pp. 137-143 More about this Journal
Abstract
The inhibitory effects of methanol extracts of 165 medicinal herbs on matrix metalloproteinase-2 (MMP-2) activity were investigated. Amongst the herbal extracts, Youngia denticulate, Platycarya strobilacea, Sedum kamtschaticum, Euscaphis japonica, and Comus controversa showed a significant inhibitory effect with above 80% at $1\;{\mu}g/ml$. Above mentioned five kind extracts, which exclude polyphenols and/or tannin by techniques for their removal, showed a mild inhibitory effect on MMP-2 activity except for Y. denticulate at the same concentration.
Keywords
matrix metalloproteinase-2; Youngia denticulate;
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