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Antithrombotic Effect of Galla Rhois  

Song, Gyu-Yong (Graduate School of East-West Medical Science, Kyunghee University)
Park, Byung-Jun (College of Oriental Medicine, Taejon University)
Kim, Sung-Hoon (Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.2, 2002 , pp. 120-123 More about this Journal
Abstract
The possibility of Galla Rhois(GR) water extract as an antithrombotic agent was investigated. The effect of GR on platelet aggregation in human platelet-rich plasma(PRP) induced by collagen and ADP in vitro and coagulation parameters in a pathological model induced by endotoxin and hydrocortisone acetate(HA) in vivo were examined. In platelet aggregation assay, GR extract significantly inhibited platelet aggregation induced by collagen and ADP in a dose-dependent manner. GR extract significantly increased the number of platelet and shortened prothrombin time(PT) and activated thromboplastin time(APTT) as compared with the control in pathological model induced by endotoxin and HA. Also, GR extract significantly increased fibrinogen level as compared with the control in a pathological model induced HA. These results suggest that GR may be a promising antithrombotic agent.
Keywords
Galla Rhois(GR) water extract; antithrombotic agent; platelet aggregation; PT; APTT;
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