Sulforaphane Post-treatment Had No Protective Effects in Paraquat-intoxicated Rats
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Jang, Gui-Sang
(Department of Emergency Medicine, Seoul National University Bundang Hospital)
Lee, Jae-Hyuk (Department of Emergency Medicine, Seoul National University Bundang Hospital) Kim, Kyuseok (Department of Emergency Medicine, Seoul National University Bundang Hospital) Jo, You Hwan (Department of Emergency Medicine, Seoul National University Bundang Hospital) Rhee, Joong Eui (Department of Emergency Medicine, Seoul National University Bundang Hospital) Lee, Kyoungbun (Department of Pathology, Seoul National University Hospital) Park, Chan Jong (Department of Emergency Medicine, Seoul National University Bundang Hospital) Kang, Chang Woo (Department of Emergency Medicine, Seoul National University Bundang Hospital) Lee, Soohoon (Department of Emergency Medicine, Seoul National University Bundang Hospital) Kim, Joonghee (Department of Emergency Medicine, Seoul National University Bundang Hospital) |
1 | Yang W, Tiffany-Castiglioni E. The bipyridyl herbicide paraquat induces proteasome dysfunction in human neuroblastoma SH-SY5Y cells. J Toxicol Environ Health 2007;70: 1849-57. DOI |
2 | Castello PR, Drechsel DA, Patel M. Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J Biol Chem 2007;282:14186-93. DOI |
3 | Yasaka T, Okudaira K, Fujito H, Matsumoto J, Ohya I, Miyamoto Y. Further studies of lipid peroxidation in human paraquat poisoning. Arch Intern Med 1986;146:681-5. DOI |
4 | Bateman DN. Pharmacological treatments of paraquat poisoning. Human Toxicol 1987;6:57-62. DOI |
5 | Piao CS, Gao S, Lee GH, Kim do S, Park BH, Chae SW, et al. Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K (ATP) channels. Pharmacol Res 2010;61:342-8. DOI |
6 | Suntres ZE. Role of antioxidants in paraquat toxicity. Toxicology 2002;180:65-77. DOI |
7 | Zhang Y, Talalay P, Cho CG, Posner G. H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 1992;89:2399-2403. DOI |
8 | Zhao HD, Zhang F, Shen G, Li YB, Li YH, Jing HR, et al. Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway. World J Gastroenterol 2010;16:3002-10. DOI |
9 | Zhao J, Kobori N, Aronowski J, Dash PK. Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 2006;393:108-12. DOI |
10 | Alp H, Aytekin I, Hatipoglu NK, Alp A, Ogun M. Effects of sulforophane and curcumin on oxidative stress created by acute malathion toxicity in rats. Eur Rev Med Pharmacol Sci 2012;16 Suppl 3:144-8. |
11 | Hong Y, Yan W, Chen S, Sun CR, Zhang JM. The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice. Acta pharmacologica Sinica 2010;31:1421-30. DOI |
12 | Innamorato NG, Rojo AI, Garcia-Yague AJ, Yamamoto M, de Ceballos ML, Cuadrado A. The transcription factor Nrf2 is a therapeutic target against brain inflammation. J Immunol 2008;181:680-9. DOI |
13 | Vomhof-Dekrey EE, Picklo MJ, Sr. The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism. J Nutr Biochem 2012;23:1201-6. DOI |
14 | Lee YJ, Jeong HY, Kim YB, Lee YJ, Won SY, Shim JH, et al. Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells. Food Chem Toxicol 2012;50:116-23. DOI |
15 | Nishina K, Mikawa K, Takao Y, Obara H. The efficacy of fluorocarbon, surfactant, and their combination for improving acute lung injury induced by intratracheal acidified infant formula. Anesth Analg 2005;100:964-71. DOI |
16 | Muftuoglu MA, Aktekin A, Ozdemir NC, Saglam A. Liver injury in sepsis and abdominal compartment syndrome in rats. Surg Today 2006;36:519-24. DOI |
17 | Choi WY, Choi BT, Lee WH, Choi YH.Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells. Bio Pharmacother 2008;62:637-44. DOI |
18 | Yu R, Lei W, Mandlekar S, Weber MJ, Der CJ, Wu J, et al. Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. J Biol Chem 1999;274:27545-52. DOI |
19 | Hu R, Hebbar V, Kim BR, Chen C, Winnik B, Buckley B, et al. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J Pharmacol Exp Ther 2004;310:263-71. DOI |
20 | Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhauser C. Nuclear factor kappa B is a molecular target for sulforaphanemediated anti-inflammatory mechanisms. J Biol Chem 2001; 276:32008-15. DOI |
21 | Jeong WS, Kim IW, Hu R, Kong AN. Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharm Res 2004;21:661-70. DOI |
22 | Kushad MM, Brown AF, Kurilich AC, Juvik JA, Klein BP, Wallig MA, et al. Variation of glucosinolates in vegetable crops of Brassica oleracea. J Agric Food Chem 1999;47:1541- 8. DOI |
23 | Guerrero-Beltran CE, Calderon-Oliver M, Pedraza-Chaverri J, Chirino YI. Protective effect of sulforaphane against oxidative stress: recent advances. Exp Toxicol Pathol 2012;64:503-8. DOI |
24 | Thejass P, Kuttan G. Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine 2007;14:538-45. DOI |
25 | Killeen ME, Englert JA, Stolz DB, Song M, Han Y, Delude RL, et al. The phase 2 enzyme inducers ethacrynic acid, DLsulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells. J Pharmacol Exp Ther 2006;316:1070-9. |
26 | Chen XL, Kunsch C. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Curr Pharma Des 2004;10:879-91. DOI |
27 | Payen L, Courtois A, Loewert M, Guillouzo A, Fardel O. Reactive oxygen species-related induction of multidrug resistance- associated protein 2 expression in primary hepatocytes exposed to sulforaphane. Biochem Biophys Res Commun 2001;282:257-63. DOI |
28 | Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. British J Clin Pharmacol 2011;72:745-57. DOI |
29 | Kang SA, Jang YJ, Park H. In vivo dual effects of vitamin C on paraquat-induced lung damage: dependence on released metals from the damaged tissue. Free Radic Res 1998;28:93- 107. DOI |
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