Browse > Article

Bone Mineral Bensity and Bone Turnover Markers in Patients with Femur Fracture Who Visited the Emergency Department  

Lee, Kyoung Mi (Department of Emergency Medicine, College of Medicine, Inha University)
Han, Seung Baik (Department of Emergency Medicine, College of Medicine, Inha University)
Kim, Jun Sig (Department of Emergency Medicine, College of Medicine, Inha University)
Baek, Kwang Je (Department of Emergency Medicine, College of Medicine, Inha University)
Hong, Seong Bin (Department of Internal Medicine, College of Medicine, Inha University)
Moon, Kyoung Ho (Department of Orthopedics, College of Medicine, Inha University)
Kang, Joon Soon (Department of Orthopedics, College of Medicine, Inha University)
Yoon, Seung-Hwan (Department of Neurosurgery, College of Medicine, Inha University)
Publication Information
Journal of Trauma and Injury / v.18, no.2, 2005 , pp. 87-93 More about this Journal
Abstract
Background: The most frequent fracture seen at the emergency department (ED) in the elderly is a femur fracture whereas they do not know the degree of osteoporosis. We analyzed the degree of osteoporosis in patients with femur fractures and compared patients with only femur fractures (FX) to patients with femur and vertebral fractures (VX) by examining the clinical features, the bone mineral density (BMD), and biochemical markers. Methods: From January 2004 to December 2004, we enrolled prospectively 30 femur fracture patients who visited the ED. The bone mineral densities of the lumbar spine and the femur were examined. Total calcium, phosphate, alkaline phosphatase, osteocalcin, and serum C-terminal telopeptide (s-CTx) were measured. The patients with femur fractures were divided into two subgroups according to the presence of vertebral fracture. Results: All BMDs of the FX group showed osteoporosis. The s-CTx levels were higher than normal. The patients in the FX with VX were older than those in the FX only group, and had lower BMDs. There were no significant differences in markers between the subgroups, but the incidence of trochanteric fractures was higher in FX with VX group than in the FX only group. Conclusion: Femur fractures in the elderly were associated with osteoporosis. In our study, despite a considerable difference in BMD between patients with femur fractures and those with femur fractures combined with vertebral fractures, there was no difference in biochemical markers on bone formation nor in the those of bone resorption. We will further investigate the biochemical markers and BMD in the population of osteoporotic fractures. So those indicators should be helpful for planning treatment and for prevention of FX in the elderly.
Keywords
Femur fracture; Osteoporosis; Bone mineral density;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Akesson K, Vergnaud P, Gineyts E, Delmas P, Obrant K. Impairment of bone turnover in elderly women with hip fracture. Calc Tissue Int 1993;53: 162 - 9   DOI   ScienceOn
2 Hoshino M. Urinary excretion of type I collagen degradation products in Healthy women and osteoporotic patients with vertebral and hip fractures. Calcif Tissue Int 1998;62:36-39   DOI   ScienceOn
3 Patrick G. Biochemical markers of bone turnover, endogeneous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner R 2000;15:1526-37
4 Sernbo I. Changes in bone mass and fracture type in patients with hip fractures. Clin Orthop 1989 ; 238 : 139 - 47
5 Lawton J, Baker M. Femoral neck fractures-two populations. Lancet 1983;july 9:70-2
6 Janet A. Serum and urine markers of bone metabolism during year after hip fracture. JAGS 2001 ; 49 : 877 - 883   DOI   ScienceOn
7 Thompson S. Changes in osteocalcin after femoral neck fracture. Ann Clin Biochem 1989;26:487-491
8 Masaaki TH, Kazuhiro KS, Kenichi NT. The degree of osteoporosisin patients with hip fracture: Relationship to incidence of vertebral fracture. J Bone Miner Metab 1999;17:187-194
9 Khan SA. Osteoporosis follow-up after wrist fractures following minor trauma. Arch Intern Med 2001 ; 161 : 1309 - 1312   DOI   ScienceOn
10 Faulkner KG. Simple measurement of femoral geometry predicts hip fracture: tje study of osteoporotic fractures. J Bone Miner Res 1993;8:1211-09 ) Hynes WC, Myers ER. Etiology and prevention of age related hip fractures. Bone 1996;18:77S-86S
11 Margareta H, Jan S, Nils D. Biochemical markers and bone density in hip fracture patients. Acta Orthop Scand 2000;71:409-413   DOI   ScienceOn
12 Libanati C. Hip mineral density in females with a recent hip fracture. J Clin Endo Metab 1996;74:351-356
13 Anonymous. Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 1993;94:646-650   DOI   PUBMED   ScienceOn
14 Sweet MB, Mendelow A, Kotler MN et al. Fractured neck of femur: Associated morbidity and mortality. S Afr J Surg 1967;5:57-64   PUBMED
15 Karlsson M K, Johnell O, Nisson B E, Sernbo I. Bone mineral mass in hip fracture patients. Bone 1993 ; 14 : 161 - 5   DOI   ScienceOn
16 Fitts WT, Lehr HB, Schor S et al. Life expectancy after fracture of the hip. Surg Gynecol Obster 1959 ; 108 : 7 - 12