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http://dx.doi.org/10.15230/SCSK.2022.48.4.313

A Study on the Potency and Stability of the Cream Containing Cannabidiol Extracted Cannabis sativa L. from Korea  

Sung Dong, Yu (Yuhan Care R&D Center, Yuhan Care Co., Ltd.)
Hye Lim, Kim (Yuhan Care R&D Center, Yuhan Care Co., Ltd.)
Ki Jun, Seong (Yuhan Care R&D Center, Yuhan Care Co., Ltd.)
Jung Tae, Jeon (Yuhan Care R&D Center, Yuhan Care Co., Ltd.)
Ae Ri, Song (Yuhan Care R&D Center, Yuhan Care Co., Ltd.)
Jong Soo, Kang (Yuhan Care R&D Center, Yuhan Care Co., Ltd.)
Il Bum, Park (Yuhan Care R&D Center, Yuhan Care Co., Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.48, no.4, 2022 , pp. 313-319 More about this Journal
Abstract
In this study, the stability of cream containing 1% of cannabidiol (CBD) with more than 99% extracted from domestic Cannabis sativa was evaluated. The pH, hardness, content, and chromaticity were measured at intervals of 2 weeks under storage conditions for each temperature for 12 weeks (4 ℃, 25 ℃, 37 ℃, and 45 ℃). The pH of the experimental group containing 1% of CBD tended to decrease more than that of the control group. As a result of measuring the change in the content of CBD in the cream under each temperature for 12 weeks using HPLC, the difference in the amount of decrement according to temperature was confirmed. It was confirmed that as a result of measuring the chromaticity using color difference meter, the yellowness of the cream containing CBD increased according to the increase by the storage period and temperature compared to the control group. From the above results, it was confirmed that the content decrease and color change according to the temperature of the pH 5 ~ 6 cream formulation containing CBD. When CBD is applied to medicine and cosmetic formulations in the future, it is considered that research and development should be conducted in consideration of the change in the quantity and physicochemical quality of CBD under the temperature.
Keywords
cannabis sativa l.; cannabidiol; cream; stability; color;
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Times Cited By KSCI : 1  (Citation Analysis)
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