Browse > Article
http://dx.doi.org/10.15230/SCSK.2022.48.2.135

Improvement of Antifungal Activity of for Water-Dispersed Cosmetic Formulations  

Lee, Ye Ji (COSMECCA KOREA)
Seo, Jae Yong (COSMECCA KOREA)
Yang, Hyeon Gap (COSMECCA KOREA)
Lee, Ju kyeong (COSMECCA KOREA)
Baek, Sol Bee (COSMECCA KOREA)
Cho, Hyun Dae (COSMECCA KOREA)
Jeong, Noh Hee (Department of Engineering Chemistry, Chungbuk National University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.48, no.2, 2022 , pp. 135-146 More about this Journal
Abstract
In order to prevent microbial contamination and safely use cosmetics, it is essential to possess preservative power. In this study, the antifungal effect was confirmed by improving the preservative system of the aqueous dispersion formulation, which has a weak preservative power against fungi, and various preservative systems were established to strengthen the preservative power against fungi. Five kinds of raw materials (sodium anisate, p-anisic acid, caprylhydroxamic acid, o-cymen-5-ol, hydroxyacetophenone) that have a benzene ring structure having a hydroxyl group and exist as protonated form in cosmetic formulations expected to improve antifungal activity in cosmetics were selected, and the minimum growth inhibitory concentration of the raw materials was determined through MIC assay. It was confirmed that the preservative power against mold was improved through the preservative efficacy test of 4 types of water dispersion formulations (cream, lotion, toner, and sun cream) in which 4 types of raw materials showing antimicrobial activity against mold were added to the preservative system. When p-anisic acid was used, it was confirmed that the preservative activity against mold was strengthened without the effect of inhibiting the preservative power against bacteria and yeast in all four formulations.
Keywords
cosmetics; preservative; microbial; antifungal; p-anisic acid;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 E. Y. Choi, Effect of phenoxyethanol and alkane diol mixture on the antimicrobial activity and antiseptic ability in cosmetics, Kor. J. Aesthet. Cosmetol., 13(2), 213 (2015).
2 Yogiara, S. J. Hwang, S. Park, J. K. Hwang, and J. G. Pan, Food-grade antimicrobials potentiate the antibacterial activity of 1,2-hexanediol, Lett. Appl. Microbiol., 60(5), 431 (2015).   DOI
3 S. Langsrud, K. Steinhauer, S. Luthje, K. Weber, P. Goroncy-Bermes, and A. L. Holck, Ethylhexylglycerin impairs membrane integrity and enhances the lethal effect of phenoxyethanol, PLoS One, doi: 10.1371/journal.pone.0165228. (2016).   DOI
4 B. Dreno, T. Zuberbier, C. Gelmetti, G. Gontijo, and M. Marinovich, Safety review of phenoxyethanol when used as apreservative in cosmetics, J. Eur. Acad. Dermatol. Venereol., 33(7 suppl), 15 (2019).
5 S. Papageorgiou, A. Varvaresou, E. Tsirivas, and C. Demetzos, New alternatives to cosmetics preservation, J. Cosmet. Sci., 61(2), 107 (2010).
6 European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by broth dilution, Clin. Microbiol. Infect., 9(8), 9 (2003).
7 A. D. Warth, Mechanism of action of benzoic acid on Zygosaccharomyces bailii: effects on glycolytic metabolite levels, energy production, and intracellular pH, Appl. Environ. Microbiol., 57(12), 3410 (1991).   DOI
8 A. Herman, Antimicrobial ingredients as preservative booster and components, Curr. Microbiol., 76(6), 744 (2019).   DOI
9 N. Halla, I. P. Fernandes, S. A. Heleno, P. Costa, Z.Boucherit-Otmani, K. Boucherit, A. E. Rodrigues, I. C. F. R. Ferreira, and M. F. Barreiro, Cosmetics preservation: A review on present strategies, Molecules, 23(7), 1571 (2018).   DOI
10 A. Varvaresou, S. Papageorgiou, E. Tsirivas, E. Protopapa, H. Kintziou, V. Kefala, and C. Demetzos, Self-preserving cosmetics, Int. J. Cosmet. Sci., 31(3), 163 (2009).   DOI
11 A. Kerdudo, F. Fontaine-Vive, A. Dingas, C. Faure, and X. Fernandez, Optimization of cosmetic preservation: water activity reduction, Int. J. Cosmet. Sci., 37(1), 31 (2014).   DOI
12 D. K. Brannan and J. C. Dille, Type of closure prevents microbial contamination of cosmetics during consumer use, Appl. Environ. Microbiol., 56(5), 1476 (1990).   DOI
13 G. W. Ahn, M. H. Choi, Y. T. Woo, and B. K. Jo, A Study on the antimicrobial effect of glyceryl caprylate in cosmetics, J. Soc. Cosmet. Sci. Korea, 33(1), 47 (2007).
14 J. Wang, Y. Liu, W. R. Kam, Y. Li, and D. A. Sullivan, Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells, Exp. Eye Res., 196, 108057 (2020).   DOI
15 W. Johnson, Jr, W. F. Bergfeld, D. V. Belsito, R. A. Hill, C. D. Klaassen, D. Liebler, J. G. Marks, Jr, R. C. Shank, T. J. Slag a, P. W. Snyder, and F. A. Andersen, Safety assessment of 1,2-glycols as used in cosmetics, Int. J. Toxicol., 31(Suppl 5), 147 (2012).
16 W. Johnson, W. F. Bergfeld, D. V. Belsito, R. A. Hill, C. D. Klaassen, D. Liebler, J. G. Marks, R. C. Shank, T. J. Slag a, P. W. Snyder, and F. Alan Andersen, Safety assessment of alkyl glyceryl ethers as used in cosmetics, Int. J. Toxicol., 32(Suppl 5), 5 (2013).
17 H. Berthele, O. Sella, M. Lavarde, C. Mielcarek, A. M. Pense-Lheritier, and S. Pirnay, Determination of the influence of factors (ethanol, pH and aw) on the preservation of cosmetics using experimental design, Int. J. Cosmet. Sci., 36(1), 54 (2014).   DOI