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http://dx.doi.org/10.15230/SCSK.2022.48.2.113

Anti-inflammation and Anti-aging Effect of Lactic Acid Bacteria Fermented Lycium chinense Extracts  

Han, Dong-Geun (Department of Cosmeceutical Science, Daegu Hanny University)
Lee, Ju-Seong (Department of Cosmeceutical Science, Daegu Hanny University)
Gal, Gyeok (Department of Cosmeceutical Science, Daegu Hanny University)
Park, Nam-Wan (R&D Center, Nature Botanics.Co., Ltd.)
Kim, Hyun-Jeong (R&D Center, HONEST.Co., Ltd.)
An, Bong-Jeon (Department of Cosmeceutical Science, Daegu Hanny University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.48, no.2, 2022 , pp. 113-121 More about this Journal
Abstract
In this study, fermented Lycium chinense (L. chinense) extract was used to analyze the efficacy of nitric oxide (NO) and anti-aging inhibition to verify its usefulness as a functional cosmetic material. L. chinense was extracted with hydrothermal and 70% ethanol as a solvent, fermented, concentrated, and freeze-dried to prepare a sample, followed by MTT assay, NO inhibition assay, western blot assay, and UPLC analysis.As a result of the analysis of NO inhibitory efficacy, fermented L. chinense water extract (FLW) and fermented L. chinense 70% ethanol extract (FLE) showed excellent NO inhibitory efficacy of 47.96% and 56.71%, respectively. As a result of measuring the expression patterns of the wrinkle-related proteins MMP-1, and TRPV-1 through Western blot, both FLW and FLE confirmed the inhibitory efficacy of MMP-1 and TRPV-1. Based on the results of the experiment, the fermented L. chinense extract is expected to have a high application value as a functional cosmetic material related anti-inflammatory, and anti-aging.
Keywords
Lycium chinense; anti-inflammation; anti-aging; MMP-1; TRPV-1;
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