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http://dx.doi.org/10.15230/SCSK.2021.47.1.49

Skin Barrier Function Enhancement Effect about Ceramide Liquid Crystal Emulsion: Similar Ratio of Skin Lipid Composition  

Han, Ji Hye (Solus Advanced Materials Co., Ltd.)
Lee, Ju Yeon (Solus Advanced Materials Co., Ltd.)
Lee, Kwan Hyoung (Solus Advanced Materials Co., Ltd.)
Kim, Hee Sun (Solus Advanced Materials Co., Ltd.)
Park, Chang Yeol (Solus Advanced Materials Co., Ltd.)
Maeng, Ji Hye (CRA Korea Inc.)
So, Ji Min (CRA Korea Inc.)
Nam, Gae Won (Dept. of Bio-Cosmetics, Seowon University)
Kim, Sang Chul (Solus Advanced Materials Co., Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.47, no.1, 2021 , pp. 49-56 More about this Journal
Abstract
In this study, a liquid crystal emulsion with a composition ratio similar to the skin lipid composition was manufactured using ceramide, glycolipids, cholesterol, and fatty acids, and a polarized microscope was used to identify liquid crystal particles in the formulation, and a cryso-SEM was used to confirm the formation of a multilayer structure. The above samples were stored at room temperature for one month and the liquid crystal structure was continuously maintained through microscopic observation. In addition, a cream composition containing liquid crystal emulsion was manufactured, and the efficiency of ceramide skin penetration was confirmed using three-dimensional artificial skin. Clinical trials were conducted using the cream composition and the results of clinical trials on skin barrier improvement were confirmed by measuring skin moisture retention (skin hydration) and transepidermal water loss (T EWL) of subjects compared to general emulsion.
Keywords
ceramide; gucosyl ceramide; liquid crystal emulsion; skin barrier function; skin permeation;
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