Development of Dermal Transduction Epidermal Growth Factor (EGF) Using A Skin Penetrating Functional Peptide
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Kang, Jin Sun
(ProCell R&D Center, ProcellTherapeutics. Inc.)
La, Ha Na (ProCell R&D Center, ProcellTherapeutics. Inc.) Bak, Sun Uk (ProCell R&D Center, ProcellTherapeutics. Inc.) Eom, Hyo Jung (ProCell R&D Center, ProcellTherapeutics. Inc.) Lee, Byung Kyu (ProCell R&D Center, ProcellTherapeutics. Inc.) Shin, Hee Je (ProCell R&D Center, ProcellTherapeutics. Inc.) |
1 | G. Carpenter and S. Cohen, Receptors and Recognition Series B, ed. R. J. Lefkowitz, 13, 43, Chapman and Hall, London (1981). |
2 | G. Carpenter and S. Cohen, Epidermal growth factor, Annu. Rev. Biochem., 48, 193 (1979). DOI |
3 | D. I. Kim, H. J. Han and S. H. Park, The effect of epidermal growth factor on cell proliferation and its related signal pathways in pig hepatocytes, J. Exp. Biomed. Sci., 12, 249 (2006). |
4 | C. D. Andl, T. Mizushima, H. Nakagawa, K. Oyama, H. Harada, K. Chruma, M. Herlyn and A. K. Rustgi, Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo, J. Biol. Chem., 278(3), 1824 (2003). DOI |
5 | B. C. Park, J. H. Lee, T. G. Kim, and Y. H. Kim, The accelerated epithelization of recombinant epidermal growth factor on partial-thickness skin wounds, Journal of Korean Burn Society, 13(2), 101 (2010). |
6 | U. S. Patent, 5618544 (1994). |
7 | M. R. Prausnitz and R. Langer, Transdermal drug delivery, Nat. Biotech., 26(11), 1261 (2008). DOI |
8 | A. Eguchi, T. Akuta, H. Okuyama, T. Senda, H. Yokoi, H. Inokuchi, S. Fujita, T. Hayakawa, K. Takeda, M. Hasegawa, and M. Nakanishi, Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells, J. Biol. Chem., 276(28), 26204 (2001). DOI |
9 | N. Ye, Y. Lin, J. Pan, S. Liu and P. Rao, PTD mediated protein transduction technology and its application in medical field, Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 28(2), 401(2011). |
10 | Z. Nemes and P. M. Steinert, Bricks and mortar of the epidermal barrier, Experimental and Molecular medicine, 31(1), 5, (1999). DOI |
11 | Korea, WO2008093982 (2008). |
12 | Korea, WO2013077680 (2013). |
13 | R. Vanbever and V. Preat, In vivo efficacy and safety of skin electroporation, Adv. Drug Deliv. Rev., 35(1), 77 (1999) DOI |
14 | G. K. Menon, New insights into skin structure: scratching the surface, Adv. Drug Deliv. Rev., 54(Suppl. 1), S3 (2002). DOI |
15 | T. Hikima, S. Ohsumi, K. Shirouzu, and K. Tojo, Mechanisms of Synergistic Skin Penetration by sonophoresis and iontophoresis, Biol. Pharm. Bull., 32(5), 905 (2009). DOI |
16 | H. Kalluri and A. K. Banga, Transdermal delivery of proteins, AAPS PharmSciTech, 12(1), 431 (2011). DOI |
17 | R. Bhagam, K. Nagaiah, P. Parvathi and L. Narasu, Simple two steps purification of rh-epidermal growth factor expressed in E.coli, Res. J. Pharm. Sci. Biotech, 1(2), 35 (2011). |
18 | B. A. Jorge, G. C. Jorge, L. S. Pedro, G. L. Tania, C. S. Maria D, L. M. Ernesto, G. N. Gerardo and H. M. Luis, Epidermal growth factor in clinical practice - a review of its biological actions, clinical indications and safety implications, Int Wound J., 6(5), 331 (2009). DOI |
19 | J. H. Lim, J. H. Kim, J. S. Kang and D. W. Jo, Partial somatic to stem cell transformations induced by cell-permeable reprogramming factors, Sci Rep, 4, 4361 (2014). |
20 | Ministry of Food and Drug Safety, Notice No 2006-6, Regulations for the designation of raw materials for cosmetics (2006). |
21 | J. H. Lim, T. Duong, G. W. Lee, B. L. Seong, W. El-Rifai, H. E. Ruley and D. W. Jo, The effect of intracellular protein delivery on the anti-tumor activity of recombinant human endostatin, Biomaterials, 34(26), 6261 (2013). DOI |
22 | J. H. Lim, J. E. Kim, T. Duong, G. W. Lee, J. H. Kim, J. N. Yoon, J. T. Kim, H. C. Kim, H. E. Ruley, W. El-Rifai and D. W. Jo, Antitumor activity of cell-permeable p18(INK4c) with enhanced membrane and tissue penetration, Mol. Ther., 20(8), 1540 (2012). DOI |
23 | H. C. Kang, S. D. Ahn, D. H. Choi, M. K. Kang, W. K. Chung, and H. G. Wu, The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study, Radiat Oncol J, 32(3), 156 (2014). DOI |
24 | J. H. Lim, T. Duong, N. Do, P. Do, J. T. Kim, H. C. Kim, W. El-Rifai, H. E. Ruley and D. W. Jo, Antitumor activity of cell-permeable RUNX3 protein in gastric cancer cells, Clin. Cancer Res., 19(3), 680 (2012). DOI |
25 | J. H. Lim, G. Y. Jang, S. E. Kang, G. W. Lee, T. T. Nga do, T. L. Phuong do, H. C. Kim, W. El-Rifai, H. E. Ruley and D. W. Jo, Cell-permeable NM23 blocks the maintenance and progression of established pulmonary metastasis, Cancer Res., 71(23), 7216 (2011). DOI |
26 |
D. J. Jeon, S. W. Kim, M. Chetana, D. W. Jo, H. E. Ruley, S. Y. Lin, D. Rabah, J. P. Kinet and H. S. Shin, Observational fear learning involves affective pain system and Cav1.2 |
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