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http://dx.doi.org/10.15230/SCSK.2018.44.4.389

Anti-aging Effect of Asterosaponin P1 Isolated from Asterina pectinifera  

Jin, Mu Hyun (Skin Research Center, R&D Park, LG Household & Health Care, Ltd.)
Lee, So Young (Skin Research Center, R&D Park, LG Household & Health Care, Ltd.)
Yeo, Hyerin (Skin Research Center, R&D Park, LG Household & Health Care, Ltd.)
Kim, Hyo Jin (Skin Research Center, R&D Park, LG Household & Health Care, Ltd.)
Chang, Yun Hee (Skin Research Center, R&D Park, LG Household & Health Care, Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.44, no.4, 2018 , pp. 389-397 More about this Journal
Abstract
The starfish, Asterina pectinifera Muller and Troschel (Asterinidae) is an indigenous species commonly found in all coasts of Korea causes damages to shellfish farms. In order to exterminate A. pectinifera, they are dried and used as fertilizer. Although various studies have been conducted to create high added value from the retrieved A. pectinifera, their actual utilization is relatively low. Accordingly, this study aimed to find new practical uses of starfish by identifying useful ingredients for skin anti-aging. Two polyhydroxysteroids and one asterosaponin were isolated from the A. pectinifera. The structures of these compounds were identified as $5{\alpha}$-cholestane-$3{\beta},6{\alpha},7{\alpha},8,15{\alpha},16{\beta},26$-heptol, $5{\alpha}$-cholestane-$3{\beta},4{\beta},6{\alpha},7{\alpha},8,15{\beta},16{\beta},2$6-octol, and asterosaponin $P_1$ on the basis of chemical and spectroscopic analysis. Among these compounds, we have found that asterosaponin $P_1$ increased epidermal stem cell proliferation and the expression of hyaluronan synthase-2 and hyaluronan synthase-3 gene, which are enzymes that synthesize water-binding matrix hyaluronic acids in keratinocytes. In addition, asterosaponin $P_1$ increased synthesis of pro-collagen type I, a major dermal collagen in fibroblasts. As a result, asterosaponin $P_1$ isolated from A. pectinifera could be used as a useful cosmetic ingredient that improves skin symptoms accompanying skin aging.
Keywords
A. pectinifera; anti-aging; starfish; asterosaponin P1; polyhydroxysteroid;
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