Effect of Steviol β-Glucopyranosyl Ester on The Production of Nitric Oxide and Inflammatory Cytokines in RAW 264.7 Cells
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Jung, Heehoon
(R&D center, Macrocare Tech Co., Ltd.)
Cho, Uk Min (School of Cosmetic Science and Beauty Biotechnology) Hwang, Hyung Seo (School of Cosmetic Science and Beauty Biotechnology) Cho, Kun (Biomedical Omics Team, Korea Basic Science Institute (KBSI)) Lee, Sang Rin (R&D center, Macrocare Tech Co., Ltd.) Kim, Moo Sung (R&D center, Macrocare Tech Co., Ltd.) |
1 | S. Shin, E. Jung, S. Kim, J. Kim, E. Kim, J. Lee, and D. Park, Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage, PLoS ONE, 8(4), e61971 (2013). DOI |
2 | J. Lim, H. Kim, and K. Kim, Nuclear factor-kappa B regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells, Lab Invest., 81(3), 349 (2001). DOI |
3 |
D. Arias-Salvatierra, E. Silbergeld, L. Acosta-Saavedra, and E. Calderon-Aranda, Role of nitric oxide produced by iNOS through NF- |
4 | T. Rhen and J. Cidlowski, Antiinflammatory action of glucocorticoids-new mechanisms for old drugs, New Engl. J. Med., 353, 1711 (2005). DOI |
5 | F. Buttgereit, G. Burmester, and B. Lipworth, Glucocorticoids and risk of cardiovascular disease, Nat. Clin. Pract. Rheumatol., 5, 18 (2009). |
6 | H. Awney, M. Massoud, and S. El-Maghrabi, Long-term feeding effects of stevioside sweetener on some toxicological parameters of growing male rats, J. Appl. Toxicol., 31, 431 (2011). DOI |
7 | J. Geuns, P. Augustijns, R. Mols, J. Buyse, and B. Driessen, Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol, Food Chem. Toxicol., 41, 1599 (2003). DOI |
8 | P. Chan, B. Tomlinson, Y. Chen, J. Liu, M. Hsieh, and J. Cheng, A double blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension, British J. Clin. Pharmacol., 50, 215 (2000). |
9 | C. Boonkaewwan and A. Burodom, Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells, J. Sci. Food. Agric., 93, 3820 (2013). DOI |
10 | C. Lee, K. Wong, J. Liu, Y Chen, J. Cheng, and P. Chan, Inhibitory effect of stevioside on calcium influx to produce antihypertension, Planta Med., 67, 796 (2001). DOI |
11 | Y. Xi, T. Yamaguchi, M. Sato, and M. Takeuch, Antioxidant mechanism of Stevia rebaudiana extract and antioxidant activity of inorganic salts, Nippon Kagaku Kaishi, 45, 317 (1998). DOI |
12 | P. Jeppesen, S. Gregersen, K. Alsrupp, and K. Hermansen, Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats, Phytomedicine, 9, 9 (2002). DOI |
13 | T. Konoshima and M. Takasaki, Cancer-chemopreventive effects of natural sweeteners and related compounds, Pure Appl. Chem., 74, 1309 (2002). DOI |
14 | U. S. Patent 14, 368, 212 (1978). |
15 | E. Yildiz-Ozturk, A. Nalbantsoy, O. Tag, and O. Yesil-Celiktas, A comparative study on extraction processes of Stevia rebaudiana leaves with emphasis on antioxidant, cytotoxic and nitric oxide inhibition activities, Ind. Crops Prod., 77, 961 (2015). DOI |
16 |
L. Fengyang, F. Yunhe, L. Bo, L. Zhicheng, L. Depeng, L. Edjie, Z. Wen, C. Yongguo, Z. Naisheng, Z. Xichen, and Y. Zhengtao, Stevioside suppressed inflammatory cytokine secretion by downregulation of NF- |
17 | G. Kaur, V. Pandhair, and G. Cheema, Extraction and characterization of steviol glycosides from Stevia rebaudiana Bertoni leaves, J. Med. Plants Studies, 2(5), 41 (2014). |
18 |
T. Wang, M. Guo, X. Song, Z. Zhang, H. Jiang, W. Wang, Y. Fu, Y. Cao, L. Zhu, and N. Zhang, Stevioside plays an anti-inflammatory role by regulating the NF- |
19 | U. Cho and H. Hwang, Anti-inflammatory effects of rebaudioside A in LPS-stimulated RAW 264.7 macrophage cells, J. soc. cosmet. scientists Korea, 43(2), 157 (2017). DOI |
20 | V. Chaturvedula and I. Prakash, Acid and alkaline hydrolysis studies of stevioside and rebaudioside A, J. App. Pharm. Sci., 1(8), 104 (2011). |
21 | M. Ishiyama, Y. Miyazono, K. Sasamoto, Y. Ohkura, and K. Ueno, A highly water-soluble disulfonated tet razolium salt as a chromogenic indicator for NADH as well as cell viability, Talanta, 44(7), 1299 (1997). DOI |
22 | L. Green, D. Wagner, J. Glogowski, P. Skipper, J. Wishnok, and S. Tannenbaum, Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids, Anal. Biochem., 126(1), 131 (1982). DOI |
23 | N. Ishimura, S. Bronk, and G. Gores, Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth, Am. J. Physiol. Gastrointest. Liver Physiol., 287(1), G88 (2004). DOI |
24 | P. Wojdasiewicz, A. Poniatowski, and D. Szukiewicz, The role of inflammatory and anti-inflammatory cyto kines in the pathogenesis of osteoarthritis, Mediat. Inflamm., Article ID 561459, 1 (2014). |
25 | J. Brown and R. Dubois, COX-2: a molecular target for colorectal cancer prevention, J. Clin. Oncol., 23, 2840 (2005). DOI |
26 | L. Marnett and R. DuBois, COX-2: a target for colon cancer prevention, Annu. Rev. Pharmacol. Toxicol., 42(1), 55 (2002). DOI |
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