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http://dx.doi.org/10.15230/SCSK.2018.44.1.31

Behaviour of Nanoemulsions Containing Ceramide IIIB and Stratum Corneum Lipids  

Cho, Wan Goo (Dept. of Functional Foods & Biotechnology, College of Medical Science, Jeonju University)
Kim, Kyung Ah (Dept. of Functional Foods & Biotechnology, College of Medical Science, Jeonju University)
Jang, Seon Il (Dept. of Healthcare & Science, Jeonju University)
Cho, Byoung Ok (Dept. of Healthcare & Science, Jeonju University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.44, no.1, 2018 , pp. 31-37 More about this Journal
Abstract
Oil/water (O/W) nanoemulsions are effective vehicles to change the permeability of the skin. In this study, we focused on the preparation and characterization of nanoemulsion which serve as colloidal carriers for the dermal application of ceramide IIIB (CIIIB) and stratum corneum (SC) lipids such as cholesterol, and palmitic acid. In order to optimize the nanoemulsions, emulsification process conditions were conducted with regard to droplet size, nanoemulsion stability, and solubility of CIIIB. A decrease in droplet size was observed through emulsification temperature of $80^{\circ}C$ and phase inversion composition (PIC) method. CIIIB has low solubility in oil and water. When the concentration of CIIIB was increased, the droplet size of nanoemulsion was increased. When Lipoid S75-3 was added to the oil phase, the solubility of CIIIB increased, indicating some interactions shown in DSC measurements. CIIIB and SC lipids could be successfully incorporated in nanoemulsions without crystallization or physical instability. In conclusion, a stable nanoemulsion containing the SC lipids could be effective as an efficient moisturizing system for skin.
Keywords
ceramides; stratum corneum lipid; nanoemulsion; PIC; HLB;
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