Browse > Article
http://dx.doi.org/10.15230/SCSK.2017.43.4.273

Stability of Nano-emulsions Containing Fatty Acid and Fatty Alcohol  

Cho, Wan Goo (College of Medical Science, Jeonju University)
Kim, Kyung Ah (College of Medical Science, Jeonju University)
Jang, Seon Il (R&D Center, Atoqna Co., Ltd.)
Cho, Byoung Ok (R&D Center, Atoqna Co., Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.43, no.4, 2017 , pp. 273-279 More about this Journal
Abstract
In this study, low viscous O/W (oil-in-water) nano-emulsion with fatty acid and fatty alcohol was prepared by phase inversion emulsification method using Tween 80 and Span 80 widely used in cosmetic products. The particle size of the nano-emulsion was increased as increasing the concentration of fatty alcohol in oil phase. Adjusting the HLB of mixed surfactants, a stable nano-emulsion with a narrow size distribution was produced. Similar change in viscosity and electrical conductivity in both systems containing fatty acid and fatty alcohol was shown in the vicinity of the phase inversion point. However, high viscosity was shown in a wide range of different aqueous fraction unlike the system consisting only oils and surfactants. The low viscous nano-emulsion with less than 100 nm droplet size was stable for one month or more at room temperature. O/W nano-emulsions with low viscosity containing fatty acid or fatty alcohol produced by low-energy emulsification method can be widely used as formulations of cosmetics.
Keywords
nano-emulsion; fatty acid; stability; fatty alcohol; Ostwald ripening;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 C. Solans, I. Sole, A. Fernandez-Arteaga, J. Nolla, N. Azemar, J. M. Gutierrez, A. Maestro, C. Gonzalez, and C. M. Pey, Surfactant Science Series 146, ed. H. A. Roque, 457, CRC Press, New York (2010).
2 Solans, P. Izquierdo, J. Nolla, N. Azemar, and M. J. Garcia-Celma, Nano-emulsions, Curr. Opin. Colloid Inter. Sci., 10, 102 (2005).   DOI
3 J. M. Gutierrez, C. Gonzalez, A. Maestro, I. Sole, C. M. Pey, and J. Nolla, Nano-emulsions: new applications and optimization of their preparation, Curr. Opin. Colloid Inter. Sci., 13, 245 (2008).   DOI
4 J. M. Asua, Miniemulsion polymerization, Prog. Polym. Sci., 27, 1283 (2002).   DOI
5 M. Antonietti and K. Landfester, Polyreactions in miniemulsions, Prog. Polym. Sci., 27, 689 (2002).   DOI
6 G. Caldero, M. J. Garcia-Celma, and C. Solans, Formation of polymeric nano-emulsions by a low-energy method and their use for nanoparticle preparation, J. Colloid Inter. Sci., 353, 406 (2011).   DOI
7 L. Wang, J. Dong, J. Chen, J. Eastoe, and X. Li, Design and optimization of a new self-nanoemulsifying drug delivery system, J. Colloid Inter. Sci., 330, 443 (2009).   DOI
8 N. Sadurni, C. Solans, N. Azemar, and M. J. Garcia-Celma, Studies on the formation of O/W nano-emulsions, by low-energy emulsification methods, suitable for pharmaceutical applications, Eur. J. Pharm. Sci., 26, 438 (2005).   DOI
9 L. Wang, X. Li, G. Zhang, J. Dong, and J. Eastoe, Oil-in-water nanoemulsions for pesticide formulations, J. Colloid Inter. Sci., 314, 230 (2007).   DOI
10 O. Sonneville-Aubrun, J. T. Simonnet, and F. L'Alloret, Nanoemulsions: a new vehicle for skincare products, Adv. Colloid Inter. Sci., 108-9, 145 (2004).   DOI
11 J. Floury, A. Desrumaux, M. A. V. Axelos, and J. Legrand, Effect of high pressure homogenisation on methylcellulose as food emulsifier, J. Food Eng., 58, 227 (2003).   DOI
12 K. Landfester, J. Eisenblatter, and R. Rothe, Preparation of polymerizable miniemulsions by ultrasonication, J. Coat. Technol. Res., 1, 65 (2004).   DOI
13 S. A. Vitale and J. L. Katz, Liquid droplet dispersions formed by homogeneous liquid-liquid nucleation: the Ouzo effect, Langmuir, 19, 4105 (2003).   DOI
14 T. Delmas, H. Piraux, A. C. Couffin, I. Texier, F. Vinet, P. Poulin, M. E. Cates, and J. Bibette, How to prepare and stabilize very small nanoemulsions, Langmuir, 27, 1683 (2011).   DOI
15 Th. F. Tadros, P. Izquierdo, J. Esquena, and C. Solans, Formation and stability of nano-emulsions, Adv. Colloid Inter. Sci., 108-09, 303 (2004).   DOI
16 W. G. Cho and S. J. Kim, Formation of skin lotions using various vehicles and skin hydration effects for a skin, J. Kor. Oil Chemists' Soc., 26(2), 1 (2009).
17 S. Sajjadi, Formation of fine emulsions by emulsification at high viscosity or low interfacial tension; a comparative study, Langmuir, 22, 5597 (2006).   DOI
18 K. Bouchemal, S. Briancon, E. Perrier, and H. Fessi, Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation, Int. J. Pharm., 280, 241 (2004).   DOI
19 H. J. Yang, W. G. Cho, and S. N. Park, Stability of oil-in-water emulsions prepared using the phase inversion composition method, J. of Ind. & Eng. Chem., 15, 331 (2009).   DOI
20 A. Forgiarini, J. Esquena, C. Gonzalez, and C. Solans, Formation of nano-emulsions by low-energy emulsification methods at constant temperature, Langmuir, 17(7), 2076 (2001).   DOI
21 E. H. Kim and W. G. Cho, Nano-emulsion formed with phospholipid-nonionic surfactant mixtures and its stability, J. Soc. Cosmet. Sci. Kor., 40(3), 221 (2014).   DOI
22 W. G. Cho, Application of nanoemulsions upon type of cosmetic oils for convergence type of cosmetics, J. Digital Convergence, 13(4), 369 (2015).   DOI