Anti-aging Cosmetic Application of Novel Multi-herbal Extract Composed of Nelumbo nucifera Leaves, Saururus chinensis and Orostachys japonica
![]() |
Baik, Minyoung
(Charmzone R&D Center, Charmzone Co. Ltd.)
Kim, Jun Hyeong (Charmzone R&D Center, Charmzone Co. Ltd.) Lee, Dae Woo (R&D Center, Dermalab Co. Ltd.) Hwang, Jae Sung (Collage of Life Sciences, Kyung Hee University) Moon, Eunjung (Charmzone R&D Center, Charmzone Co. Ltd.) |
1 | H. J. Nam and Y. B. Kim, Aging and skin aging, J. Orient. Med. Ophthalmol. Otolaryngol. Dermatol., 17(1), 16 (2004). |
2 | J. M. Han, S. W. Ko, and H. J. Yoon, The study on the korean and western medical literatures for aging and skin aging, J. Kor. Med. Ophthalmol. Otolaryngol. Dermatol., 27(1), 45 (2014). DOI |
3 | K. H. Cho, M. K. Lee, S. J. Jo, K. H. Kim, K. C. Park, H. C. Eun, and J. H. Chung, Histologic changes in the skin with photoaging, Kor. J. Dermatol., 41(6), 754 (2003). |
4 | T. Quan, Z. Qin, W. Xia, Y. Shao, J. J. Voorhees, and G. J. Fisher, Matrix-degrading metalloproteinases in photoaging, J. Investig. Dermatol. Symp. Proc., 14(1), 20 (2009). DOI |
5 | D. Darr and I. Fridovich, Free radicals in cutaneous biology, J. Investig. Dermatol., 102(5), 671 (1994). DOI |
6 | G. J. Fisher, S. Kang, J. Varani, Z. Bata-Csorgo, Y. Wan, S. Datta, and J. J. Voorhees, Mechanisms of photoaging and chronological skin aging, Arch. Dermatol., 138(11), 1462 (2002). |
7 | E. J. Cho, T. Yokozawa, D. Y. Rhyu, S. C. Kim, N. Shibahara, and J. C. Park, Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl- 2-picrylhydrazyl radical. Phytomedicine, 10(6-7), 544 (2003). DOI |
8 | M. J. Ryu and S. Y. Lee, Antioxidant effects of Plantago asiatica and protective effect sonhuman HaCaT keratinocyte, J. Kor. Soc. Beauty Cult. Arts, 11(3), 15 (2010). |
9 | J. K. Hong, A study on skin aging caused by free-radical and on efficacy of antioxidant vitamins, Kor. J. Aesth. Soc., 7(2), 51 (2009). |
10 | N. Lynch and D. Berry, Differences in perceived risks and benefits of herbal, over-the-counter conventional, and prescribed conventional, medicines, and the implications of this for the safe and effective use of herbal products, Complement. Ther. Med., 15(2), 84 (2007). DOI |
11 | M. Pulok, M. Debajyoti, M. Amal, and H. Michael, The sacred lotus (Nelumbo nucifera) - Phytochemical and therapeutic profile, J. Pharm. Pharmacol., 61(4), 407 (2009). DOI |
12 | D. Y. Shin, W. S. Lee, J. H. Jung, S. H. Hong, C. Park, H. J. Kim, G. Y. Kim, H. J. Hwang, G. S. Kim, J. M. Jung, C. H. Ryu, S. C. Shin, S. C. Hong, and Y. H. Choi, Flavonoids from Orostachys japonicus A. Berger Inhibit the Invasion of LnCaP Prostate Carcinoma Cells by Inactivating Akt and Modulating Tight Junctions, Int. J. Mol. Sci., 14(9), 18407 (2013). DOI |
13 | Y. Kashiwada, A. Aoshima, Y. Ikeshiro, Y. P. Chen, H. Furukawa, M. Itoigawa, T. Fujioka, K. Mihashi, L. M. Cosentino, S. L. Morris Natschke, and K. H. Lee, Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera and structure-activity correlations with related alkaloids, Bioorg. Med. Chem., 13(2), 443 (2005). DOI |
14 | S. R. Kang, E. Y. Park, M. S. Park, J. Park, and Y. C. Park, Antioxidative and collagen synthetic abilities of Gardeniae fructus and Saururus chinensis water extracts, J. Investig. Cosmetol., 7(2), 165 (2011). DOI |
15 | C. S. Kang, M. J. LEE, C. B. Park, and I. S. Bang, Study on the antioxidative and physiological activities of Saururus chinensis extract, J. Life Sci., 22(6), 807 (2012). DOI |
16 | J. Y. Hwang, J. Zhang, M. J. Kang, S. K. Lee, H. A. Kim, and J. I. Kim, Hypoglycemic and hypolipidemic effects of Sarurus chinensis baill in streptozotocin- induced diabetic rats, Nutrit. Res. Pract., 1(2), 100 (2007). DOI |
17 | H. J. Kim, J. Y. Lee, S. M. Kim, D. A. Park, C. B. Jin, S. P. Hong, and Y. S. Lee, A new epicatechin gallate and calpain inhibitory activity from Orostachys japonicas, Fitoterapia, 80(1), 73 (2009). DOI |
18 | H. J. Park, H. S. Young, K. Y. Park, S. H. Rhee, H. Y. Chung, and J. S. Choi, Flavonoids from the whole plants of Orostachys japonicas, Arch. Pharm. Res., 14(2), 167 (1991). DOI |
19 |
Y. S. Yoon, K. S. Kim, S. G. Hong, B. J. Kang, M. Y. Lee, and D. W. Cho, Protective effects of Orostachys japonicas A. Berger (Crassulaceae) on |
20 | N. Y. Yoon, B. S. Min, H. K. Lee, J. C. Park, and J. S. Choi, A potent anti - complementary acylated sterol glucoside from Orostachys japonicas, Arch. Pharm. Res., 28(8), 892 (2005). DOI |
21 | M. J. Kim, S. W. Woo, M. S. Kim, J. E. Park, and J. K. Hwang, Anti-photoaging effect of aaptamine in UVB irradiated human dermal fibroblasts and epidermal keratinocytes, J. Asian Nat. Prod. Res., 16(12), 1139 (2014). DOI |
22 | H. S. Lee, D. Bilehale, G. S. Lee, D. S. Ryu, H. K. Kim, D. H. Suk, and D. S. Lee, Anti-inflammatory effect of the hexane fraction from Orostachys japonicus in RAW264.7 cells by suppression of NF-TEX>${\kappa}B$ and PI3K-Akt signaling, Journal of functional food, 5, 1217 (2013). DOI |
23 | C. H. Kim, J. H. Park, J. K. Lim, K. J. Lee, G. Y. Chung, and H. J. Jeong, The activity of antioxidants and suppression of cancer cell proliferation in extracts of Orostachys japonicas A. Berger, Korean J. Medicinal Crop Sci., 11(1), 31 (2003). |
24 | J. H. Lee, S. J. Lee, S. M Park, H. K. Kim, W. Y. Jeong, J. Y Choi, N. J. Sung, W. S. Lee, C. S. Lim, G. S. Kim, and S. C. Shin, Characterisation of flavonoids in Orostachys japonicus A. Berger using HPLC-MS/MS: Contribution to the overall antioxidant effect, Food Chemistry, 124(4) 1627 (2011). DOI |
25 |
M. S. Kim, Y. G. Park, H. J. Lee, S. J. Lim, and C. W. Nho, Youngiasides A and C isolated from Youngia denticulatum inhibit UVB-induced MMP expression and promote type I procollagen production via repression of MAPK/ AP-1/NF- |
26 | J. L. Song and Y. Gao, Protective effects of Lindera coreana on UVB-induced oxidative stress in human HaCaT keratinocytes, Iran. J. Pharmaceut. Res., 13(4), 1369 (2014). |
27 | Y. C. Hou, A. Janczuk, and P. G. Wang, Current trends in the development of nitric oxide donors, Curr. Pharmaceut. Design, 5(6), 417 (1999). |
28 | G. A. Di Lullo, S. M. Sweeney, J. Korkko, L. Ala-Kokko, and J. D. San Antonio, Mapping the ligand- binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen, J. Biol. Chem., 277(6), 4223 (2002). DOI |
29 | W. Cheng, R. Yan-hua, N. Fang-gang, and Z. Guo-an, The content and ratio of type I and III collagen in skin differ with age and injury, Afr. J. Biotechnol., 10(13), 2524 (2011). |
30 | Y. H. Rong, G. A. Zhang, and C. Wang, Quantification of type-I and type-III collagen content of normal skin among groups of different ages, Chin. J. Burns, 24(1), 51 (2008). |
31 | T. Osanai, N. Fujiwara, M. Saitoh, S. Sasaki, H. Tomita, M. Nakamura, H. Osawa, and H. Yamabe, Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease, Blood Purify, 20(5), 466 (2002). DOI |
32 | N. Akdeniz, A. Aktas, T. Erdem, M. Akyuz, and S. Ozdemir, Nitric oxide levels in atopic dermatitis, Pain Clin., 16(4), 401 (2013). |
33 | S. H. Eom, E. H. Lee, K. B. H. Park, J. Y. Kwon, P. H. Kim, W. K. Jung, and Y. M. Kim, Eckol from Eisenia bicyclis inhibits inflammation through the AKT/NF-kB signaling in Propionibacterium acnes-induced human keratinocyte HaCaT Cells, J. Food Biochem., http://dx.doi.org/10.1111/jfbc.12312 (2016). DOI |
34 | Q. T. Smith, Clinical and Biological Springer US Aspects, 31, Collagen metabolism in wound healing (1975). |
![]() |