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http://dx.doi.org/10.15230/SCSK.2017.43.2.115

Studies on Skin Whitening Effects of Resorcinol Dipentyl Ether  

Cha, Young Kwon (Cosmecca Korea, CIR Center)
Cho, Hyun Dae (Cosmecca Korea, CIR Center)
Cho, Wan Goo (Department of Functional Food & Biotechnology, Jeonju University)
Byun, Sang Yo (Cosmetic Science Major, Applied Biotechnology Department, Graduate School, Ajou University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.43, no.2, 2017 , pp. 115-124 More about this Journal
Abstract
The objective of this study was to investigate skin whitening effect of Resorcinol dipentyl ether [1,3-di(pentyloxyl)benzene] by in vitro experiments. Resorcinol dipentyl ether was prepared by alkylation of resorcinol with 1-bromopentane. The reaction products were confirmed by NMR, MS and other analytical equipments. In order to evaluate the skin safety of resorcinol dipentyl ether, the cytotoxicity of the cells constituting the skin (keratinocyte, melanocyte, fibroblast) was analyzed and similar cell viability was observed in all cell lines as compared with the control group. Inhibition of extracellular melanin synthesis effect of resorcinol dipentyl ether was approximately 65.75% at $20{\mu}g/mL$ and inhibition of intracellular melanin synthesis effect of resorcinol dipentyl ether was approximately 53.89% at $20{\mu}g/mL$. The real-time PCR and western blot analysis of mRNA expression and protein expression of tyrosinase, TRP-1, and TRP-2 related to melanogenesis revealed that melanin inhibitory effect of resorcinol dipentyl ether was inhibited from the transcription stage respectively. Finally, this study suggested applicability of Resorcinol dipentyl ether [1,3-di(pentyloxyl)benzene] as a whitening functional cosmetic new material.
Keywords
Resorcinol dipentyl ether; melanin; MTT assay; tyrosinase; mRNA;
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