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http://dx.doi.org/10.15230/SCSK.2017.43.1.11

Electrospray-assisted Preparation of Polymer Microparticles Containing Water-insoluble Bioactive Compounds  

Hwang, Yoon Kyun (Amorepacific Corporation/R&D Center)
Jeong, Min Kuk (Department of Chemical Engineering, Hanyang University)
Cho, Sung Yeon (Department of Chemical Engineering, Hanyang University)
Park, Sung Il (Amorepacific Corporation/R&D Center)
Cho, Eun Chul (Department of Chemical Engineering, Hanyang University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.43, no.1, 2017 , pp. 11-18 More about this Journal
Abstract
An anti-aging compound ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) rapidly crystallizes in emulsion systems, and a flavonoid 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone bearing a whitening function causes coloration of cosmetic compounds when mixed with metal oxides. In this study, an electrospray method was used to encapsulate water-insoluble bioactive compounds in polymeric microparticles. Poly (methyl methacrylate) and polycaprolactone were used to encapsulate ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) and 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone, respectively. It was found that polymer concentration, the structure of electrospray nozzle, and compatibility between polymers and bioactive compounds were important factors in the preparation of the particles. Polycaprolactone particles encapsulating 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone was effective in preventing coloration of a cosmetic compound when mixed with metal oxides.
Keywords
electrospray; polymer microparticles; water-insoluble bioactive compounds; prevention of coloration;
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