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http://dx.doi.org/10.15230/SCSK.2016.42.4.433

Self-assembly of Retinoic Acid-conjugated Poly(Amino Acid)'s Derivative  

Han, Sa Ra (Dept. of Chemical Engineering, Soongsil University)
Lee, Hyeongyeong (Dept. of Chemical Engineering, Soongsil University)
Kim, Hee-Jin (Dept. of Chemical Engineering, Soongsil University)
Cho, Yoon Na (Dept. of Chemical Engineering, Soongsil University)
Lee, Seung-Jun (Dept. of Chemical and Biomolecular Eng., KAIST)
Zhoh, Choon-Koo (Dept. of Chemical Engineering, Soongsil University)
Jeong, Jae Hyun (Dept. of Chemical Engineering, Soongsil University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.42, no.4, 2016 , pp. 433-440 More about this Journal
Abstract
In this study, a poly (amino acid)s derivative grafted with retinoic acids, which could form self-assemblies in an aqueous solution, was successfully synthesized. The synthesized amphiphilic poly (amino acid)s were controlled with 5, 10, 30 mol% substitution of retinoic acid. Then, the amphiphilic poly (amino acid)s were self-assembled by inter/intra molecular stacking of retinoic acids in an aqueous solution. Also, the increasing the degree of substitution (DS) of retinoic acids decreased the size of self-assembled nanoparticles and induced structural transition to bilayer structure from spherical structure. The retinol was stably encapsulated into a core of self-assembled nanoparticle with 10 mol% of DS. This strategy to prepare the self-assemblies of amphiphilic polyaspartamide will serve to improve the efficiency of targeted delivery for a functional cosmetic with various biological modalities.
Keywords
polyaspartamide; retinol; self-assembly; degree of substitution;
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