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http://dx.doi.org/10.15230/SCSK.2016.42.3.203

Hair Growth-promoting Effect of Resina Pini and Its Main Constituent, Abietic Acid, in Mouse Model of Alopecia  

Park, Gunhyuk (The K-herb Research Center, Korea Institute of Oriental Medicine)
Kim, Yong-ung (Department of Pharmaceutical Engineering, College of Biomedical Science, Daegu Haany University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.42, no.3, 2016 , pp. 203-209 More about this Journal
Abstract
Recently, increased attention has been directed toward medicinal extracts and their active ingredients as potential new drug candidates for androgenic alopecia. Resina Pini (RP), a resinous exudation obtained from Pinus sp. (Pinaceae), has been used as a traditional medicine for the treatment of infection, pain related to dental caries, and periodontal disease. Previously, we suggested that RP and its main constituent, abietic acid (abieta-7,13-dien-18-oic acid; AA), may play important roles against androgenic alopecia as $5{\alpha}$-reductase inhibitors. However, to date, there is no evidence that AA has hair growth-promoting effects in vivo. In this study, we found that 10 ~ 300 mg/kg RP and 3 ~ 30 mg/kg AA significantly promoted hair growth in a C3H/HeN mouse model of alopecia. To our knowledge, this is the first report of the hair growth-promoting effects of RP and AA in vivo. From these results, RP and its main constituent AA can promote hair growth in mouse by inhibiting $5{\alpha}$-reductase activity and may be effective alternative therapies for androgenic alopecia.
Keywords
hair growth; Resina Pini; abietic acid; androgenic alopecia; mouse model; $5{\alpha}$-reductase inhibitor;
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