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http://dx.doi.org/10.15230/SCSK.2016.42.1.29

Formation of Nano-emulsions with Resorcinol bis-ethylhexanoate upon Type of Emulsifiers  

Cho, Wan Goo (College of Medical Science, Jeonju University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.42, no.1, 2016 , pp. 29-35 More about this Journal
Abstract
RS White (resorcinol bis-ethylhexanoate) is used in cosmetics as a skin whitening agent. In this study, we studied the possibility of nano-emulsion formation containing whitening agent, RS White, with different types of emulsifying agents. With Tween 80, 60, HCO 60 and 40 as a hydrophilic surfactants and Span 80 as ahydrophilic surfactant, nano-emulsions were formed at appropriate concentrations, but they were not formed in the system using the Myrj 52, Montanov L, and Tegocare 450 with Span 80. The diameter of nano-emulsion sphere was smaller than 100 nm. The emulsion showed a translucent appearance and maintained stability in stability evaluation with time. In vitro skin permeation experiments showed that amounts of skin permeated nano-emulsion for 24 h were $70.84{\mu}g/cm^2$ and those of O/W emulsion were $28.97{\mu}g/cm^2$. In conclusion, a stable nano-emulsion containing the resorcinol bis-ethylhexanoate is effective for potential efficacy system as an efficient delivery system of the functional materials into skin.
Keywords
nano-emulsion; resorcinol bis-ethylhexanoate; emulsifier; absorption; PIC;
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Times Cited By KSCI : 5  (Citation Analysis)
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