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http://dx.doi.org/10.15230/SCSK.2015.41.4.383

Inhibitory Effect of Ginkgo biloba Extracts on Melanin Biosynthesis  

Kim, Yoon Suk (Department of Herbal Cosmetics Science, Reasearch institute for basic Sciences, Hoseo University)
Lee, Young Hwa (Department of Herbal Cosmetics Science, Reasearch institute for basic Sciences, Hoseo University)
Lee, Jin Young (Department of Herbal Cosmetics Science, Reasearch institute for basic Sciences, Hoseo University)
Yi, Yong sub (Department of Herbal Cosmetics Science, Reasearch institute for basic Sciences, Hoseo University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.41, no.4, 2015 , pp. 383-389 More about this Journal
Abstract
In this study, we investigated the inhibitory effect on melanin synthesis of Ginkgo biloba seed oil. The results showed 9.96% inhibitory effect scavenging activity on DPPH and showed a value of 1.33 mM of $FeSO_4$ at a concentration of 0.06% in DMSO by using FRAP assay. G. biloba seed oil inhibited tyrosinase activity up tp 37.72% and suppressed the biosynthesis melanin up to 48.02% at 0.06% in B16/F10 mouse melanoma cell. In G. biloba seed oil treated group tyrosinase, TRP-1, TRP-2 and MITF gen expression levels significantly decreased compared to the contral group at a concentration of 0.04% and 0.06%. In conclusion, these results indicated that G. biloba seed oil extract have a good antimelanogenetic effects.
Keywords
Ginkgo biloba; DPPH activity; melanin; oil; antimelanogenetic;
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1 D. S. Kim, S. H. Park, S. B. Kwon, S. W. Youn, and K. C. Park, Effects of lysophosphatidic acid on melanogenesis, Chem. Phys. Lipids., 127(2), 199. (2004).   DOI
2 S. Ito, The IFPCS presidential lecture: a chemist's view of melanogenesis, Pigment Cell Res., 16, 230 (2003).   DOI
3 J. Cabanes, S. Chazarra, and F. Garcia-Carmona, Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase, J. Pharm. Pharmacol., 46(12), 982 (1994).   DOI
4 J. S. Chen, C. Wei, and M. R. Marxhall, Inhibition mechanism of koji acid on polyphenol oxidase, J. Agr. Food Chem., 39(11), 1897 (1991).   DOI
5 K. Urabe, P. Aroca, K. Tsukamoto, D. Mascagna, A. Paulumbo, G. Prota, and V. J. Hering, The inherent cytotoxicty of melanin precursors, BBA-Mol. Cell. Res., 1221(3), 272 (1994).
6 R. Busca and R. Ballotti, Cyclic AMP a key messenger in the regulation of skin pigmentation, Pigment Cell Res., 13(2), 60 (2000).   DOI
7 C. P. Sassone, Coupling gene expression to cAMP signalling: Role of CREB and CREM, Int. J. Biochem. Cell Biol., 30(1), 27 (1998).   DOI
8 B. Saha, S. K. Singh, C. Sarkar, R. Bera, J. Ratha, D. J. Tobin, and R. Bhadra, Activation of the MITF promoter by lipid-stimulated activation of p38-stress signalling to CREB, Pigment Cell Res., 19(6), 595 (2006).   DOI
9 S. Parvez, M. Kang, H.-S. Chung, C. Cho, M.-C. Hong, M.-K. Shin, and H. Bae, Survey and mechanism of skin depigmenting and lightening agents, Phytother. Res., 20(11), 921 (2006).   DOI
10 N. Baurin, E. Arnoult, T. Scior, Q. T. Do, and P. Bernard, Preliminary screening of some tropical plants for anti-tyrosinase activity, J. Ethnopham, 82(2-3), 155 (2002).   DOI
11 V. J. Hearing and K. Tsukamoto, Enzymatic control of pigmentation in mammals, FASEB J., 5(14), 2902 (1991).   DOI
12 G. Prota, The chemistry of melanins and melanogenesis, Prog. Chem. Org. Nat. Prod., 64, 93 (1995).
13 J. Yamakoshi, F. Otsuka, A. Sano, S. Tokutake, M. Saito, M. Kikuchi, and Y. Kubota, Lightening effect on ultraviolet induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin rich extract from grape seeds, Pigment Cell Res., 16(6), 629 (2003).   DOI
14 B. P. Jacobs and W. S. Browner, Ginkgo biloba: a living fossil, Am. J. Med., 108(4), 341 (2000).   DOI