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http://dx.doi.org/10.15230/SCSK.2015.41.3.237

Anti-inflammatory Effect of Fallopia sachalinensis RonseDecr. Fruit  

Park, Sung Ha (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center)
Jeong, Jeong Hyeon (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center)
Park, Byoung Jun (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center)
Jeong, Tae Hwa (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.41, no.3, 2015 , pp. 237-241 More about this Journal
Abstract
To develop a new anti-inflammation agent for cosmetics, we investigated the anti-inflammatory activity of Fallopia sachalinensis RonseDecr. fruit extracts (FSR). FSR inhibited the pre-inflammatory cytokines ($1L-1{\beta}$, IL-6, TNF-${\alpha}$) and reduced NO production of RAW 264.7 macrophage cells in a dose-dependent manner and decreased the activity to about 51% at a concentration of $100{\mu}g/mL$. FSR suppressed not only the mRNA expression of iNOS and COX-2, but also the protein expression of iNOS and COX-2 in macrophage. The results suggested that FSR has considerable potential as a cosmetics ingredient with an anti-inflammatory effect.
Keywords
Fallopia sachalinensis RonseDecr.; anti-inflammatory;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 K. A. Hogquist, T. A. Baldwin, and S. C. Jameson, Central tolence: learning self-control in the thymus, Nat. Rev. Immunol., 5(10), 772 (2005).   DOI
2 B. H. Kim, Y. T. Lee, and K. H. Kang, Codonopsis Lanceolata inhibits inflammation through regulation of MAPK in LPS-stimulated RAW 264.7 cells, Korean J. Oriental Physiology and Pathology, 24(1), 80 (2010).
3 T. H. Oh, Ph. D. Dissertation, Jeju National Univ., Jeju, Korea (2011).
4 W. S. Choi, H. S. Kwon, R. H. No, G. P. Choi, and H. Y. Lee, Enhancement of anti-inflammatory activities of fermented scutellaria baicalensis extracts using Lactobacillus rhamnosus, J. Soc. Cosmet. Scientists Korea, 39(4), 303 (2013).   DOI
5 M. J. Park and J. H. Jeong, Cedrela sinensis leaves suppress oxidative stress and expressions of iNOS and COX-2 via MAPK signaling pathways in RAW 264.7 cells, J. FOOD Sci. Nutr., 14, 269 (2009).   DOI
6 D. Hwang, B. C. Jang, G. Yu, and B. Mary, Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide, Biochem. Pharmacol., 54(1), 87 (1997).   DOI
7 Y. H. Seo, O. H. Kang, D. Y. Kwon, J. S. Lee, and J. H. Han, Study on the anti-inflammatory effect of Jakyak-tang water extract, Korean J. Oriental & Pathology, 25(3), 503 (2011).
8 M. E. Assar and J. Angulo, Oxidative stress and vascular inflammation in aging, Free Radic. Biol. Med., 65, 380 (2013).   DOI