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http://dx.doi.org/10.15230/SCSK.2013.39.4.289

Whitening Effect of Biochanin A  

Park, Sung Ha (Bio Materials R&D center, Kolmar Korea, CBTP, Future Convergent Tch Center)
Kim, A Hyun (Bio Materials R&D center, Kolmar Korea, CBTP, Future Convergent Tch Center)
Park, Byoung Jun (Bio Materials R&D center, Kolmar Korea, CBTP, Future Convergent Tch Center)
Kim, Jin Jun (Bio Materials R&D center, Kolmar Korea, CBTP, Future Convergent Tch Center)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.39, no.4, 2013 , pp. 289-294 More about this Journal
Abstract
To develop a new whitening agent for cosmetics, we investigated the inhibitory effects of biochanin A on melanogenesis. The biochanoin A is an active component in the extracts of Dalbergia odorifera T. Chen. It reduced melanin contents of B16F1 melanoma cells in a dose-dependent manner and decreased to about 48% at a concentration 10 ${\mu}g/mL$. It also inhibited the expression in microphthalmia associated transcription factor (MITF), Tyrosinase, Tyrosinase related protein 1 (Trp-1), and Tyrosinase related protein 2 (Trp-2) in melanocytes. The results suggested that biochanin A has considerable potential as a cosmetics ingredient with a whitening effect.
Keywords
Biochanin A; whitening; melanin; Dalbergia odorifera T.CHEN;
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Times Cited By KSCI : 2  (Citation Analysis)
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