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http://dx.doi.org/10.15230/SCSK.2012.38.1.067

Hypopigmentary Effects of Dipeptides in B16 Melanoma Cells  

Nam, Hee-Seung (Department of Biochemistry, Chung-Ang University College of Medicine)
Kim, Eun-Hyun (Department of Biochemistry, Chung-Ang University College of Medicine)
Kim, Su-Yeon (Department of Biochemistry, Chung-Ang University College of Medicine)
Lee, Hyun-E (Department of Biochemistry, Chung-Ang University College of Medicine)
Hong, Ji-Yun (Department of Biochemistry, Chung-Ang University College of Medicine)
Lee, Jae-Guk (Department of Biochemistry, Chung-Ang University College of Medicine)
Cho, Sung-Tai (Department of Biochemistry, Chung-Ang University College of Medicine)
Cho, Yang-Hwan (Department of Biochemistry, Chung-Ang University College of Medicine)
Yun, Hye-Young (Department of Biochemistry, Chung-Ang University College of Medicine)
Baek, Kwang-Jin (Department of Biochemistry, Chung-Ang University College of Medicine)
Kwon, Nyoun-Soo (Department of Biochemistry, Chung-Ang University College of Medicine)
Min, Young-Sil (Department of Herb Industry, Jungwon University)
Park, Kyoung-Chan (Department of Dermatology, Seoul National University College of Medicine)
Kim, Dong-Seok (Department of Biochemistry, Chung-Ang University College of Medicine)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.38, no.1, 2012 , pp. 67-73 More about this Journal
Abstract
In the present study, we investigated the effects of dipeptides on melanogenesis in B16 melanoma cells. It was found that WV (Trp+Val), WM (Trp+Met), and CQ (Cys+Gln) decreased melanin production dosedependently. However, dipeptides did not directly inhibit tyrosinase activity, the rate-limiting melanogenic enzyme. Therefore, we further investigated the expression of tyrosinase. Our results showed that ${\alpha}$-MSH-induced tyrosinase expression was down-regulated by WV, WM, and CQ. Thus, we propose that WV, WM, and CQ show hypopigmentary activity through tyrosinase down-regulation.
Keywords
$\alpha$-MSH; dipeptides; melanogenesis; tyrosinase; melanin;
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