Browse > Article
http://dx.doi.org/10.15230/SCSK.2011.37.3.275

Whitening Efficacy Study of Natural Compounds-Peptide Derivatives via cAMP Signaling Pathway  

Lee, Hye-Suk (Central Research, Aekyung R&D Center)
Shin, Kyong-Hoon (Central Research, Aekyung R&D Center)
Ryu, Geun-Seok (Central Research, Aekyung R&D Center)
Jee, Kyung-Yup (Central Research, Aekyung R&D Center)
Cho, In-Shik (Central Research, Aekyung R&D Center)
Kim, Han-Young (Central Research, Aekyung R&D Center)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.37, no.3, 2011 , pp. 275-282 More about this Journal
Abstract
Novel whitening agents were prepared using peptide-Natural origin compound derivatives. The peptide could be an antagonist of MC1R and Natural origin compound were well-known material as a Tyrosinase inhibitor. We also suggest the new assay method which could evaluate the Antagonistic effectiveness to MC1R using cAMP signaling pathway. 24 candidates were synthesized and 11 peptide derivatives were selected by cAMP assay method. To evaluate cAMP assay, the selected peptide derivatives were assayed to evaluate their melanogensis inhibitory activity. At this work, we could know that the sequences which include -RW- have a melanogensis inhibitory activity, and cAMP assy could use as a evaluating method of MC1R antagonist. But, to evaluate the whitening activity of some material, cross-checking with melanin inhibitory assay method was recommended.
Keywords
${\alpha}$-MSH; MC1R; antagonist; cAMP; melanogenesis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 T. Takuji, S. Chikara, O. Kenkichi, and S. Keikichi, Melanocyte-stimulating hormone inhibitor and external preparation containing the same, European Patent Application, Publication number EP 0 389 950 A1.
2 A. M. Lopez-Contreras, J. H. Martinez-Liarte, F. Solano, P. Samaraweera, J. M. Newton, and J. T. Bagnara, The amphibian melanization inhibiting factor (MIF) blocks the alpha-MSH effect on mouse malignant melanocytes, Pigment Cell Res., 9(6), 311 (1996).   DOI   ScienceOn
3 T. Brzoska, T. A. Luger, C. Maaser, C. Abels, and M. Bṏhm, $\alpha$-Melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo and future perspectives for the treatment of immune- mediated inflammatory diseases, Endocrine Reviews, 29(5), 581 (2008).   DOI   ScienceOn
4 S. Froidevaux and A. N. Eberle, Homologous regulation of melanocortin-1 receptor (MC1R) expression in melanoma tumor cells in vivo, J Recept Signal Transduct Res., 22(1-4), 111 (2002).   DOI
5 V. J. Hruby, G. Han, and M. E. Hadley, Design and bioactivities of melanotropic peptide agonists and antagonist: Design based on a conformationally constrained somatostatin template, Letters in Peptide Science, 5, 117 (1998).
6 T. K. von Almen, G. A. Olson, and R. D. Olson, Behavioral effects of melanocyte stimulating hormone release-inhibiting factor-1, Neuroscience & Biobehavioral Reviews, 7(2), 257 (1983).   DOI   ScienceOn
7 WO2007137015A2, Dermatological uses of tri-, tetra-, penta-, and polypeptides.
8 T. Kobayashi, W. D. Vieira, B. Potterf, C. Sakai, G. Imokawa, and V. J. Hearing, Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis, J. Cell. Sci., 108, 2301 (1995).
9 C. Sakai, M. Ollmann, T. Kobayashi, Z. Abdel- Malek, J. Muller, W. D. Vieira, G. Imokawa, G. S. Barsh, and V. J. Hearing, Modulation of murine melanocyte function in vitro by agouti signal protein, EMBO J., 12, 3544 (1997).
10 K.-H. Shin, J. H. Lee, G. S. Ryu, K. Y. Jee, S. N. Park, J. I. Kim, I. S. Cho, and H.-Y. Kim, Preparation of natural compounds-tripeptides derivatives and their melanogensis inhibitory activity, J. Soc. Cosmet. Scientists Korea, 36(3), 233 (2010).
11 S. Im, O. Moro, F. Peng, E. E. Medrano, J. Cornelius, G. Babcock, J. J. Nordlund, and Z. A. Abdel-Malek. Activation of cyclic AMP pathway by a-melanotropin mediates the response of human melanocytes to ultraviolet B radiation, Cancer Res., 58, 47 (1998).
12 S. Shibahara, K. Takeda, K. Yasumoto, T. Udono, K. Watanabe, H. Saito, and L. Takahashi, Microphthalmia- associated transcription factor (MITF): multiplicity in structure, function, and regulation, J. Invest. Dermatol. Symp Proc., 6, 99 (2001).   DOI   ScienceOn
13 R. Busca and R. Ballotti, Cyclic AMP a key messenger in the regulation of skin pigmentation, Pigment Cell Res., 13, 60 (2000).   DOI   ScienceOn
14 M. Tachibana, MITF: a stream flowing for pigment cells, Pigment Cell Res., 13, 230 (2000).   DOI   ScienceOn
15 C. Bertolotto, R. Busca, P. Abbe, K. Bille, E. Aberdam, J.-P. Ortonne, and R. Ballotti, Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia, Mol. Cell. Biol., 18, 694 (1998).   DOI
16 E. R. Price, H.-F. Ding, T. Badalian, S. Bhattacharya, C. Takemoto, T.-P. Yao, T. J. Hemesath, and D. E. Fisher, Lineage-specific signaling in melanocytes. c-Kit stimulation recruits p300/CBP to microphthalmia, J. Biol. Chem., 273, 17983 (1998).   DOI
17 K. Schallreuter, A. Slominski, J. M. Pawelek, K. Jimbow, and B. A. Gilchrest, What controls melanogenesis?, Exp. Dermatol., 7, 143 (1998).   DOI   ScienceOn
18 R. D. Cone, D. Lu, S. Koppula, D. I. Vage, H. Klungland, B. Boston, W. Chen, D. N. Orth, C. Pouton, and R. A. Kesterson. The melanocortin receptors: agonist, antagonist, and the hormonal control of pigmentation, Recent Prog. Horm. Res., 51, 287 (1996).
19 C. Bertolotto, P. Abbe, T. J. Hemesath, K. Bille, D. E. Fisher, J. P. Ortonne, and R. Ballotti. Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes, J. Cell. Biol., 142, 827(1998).   DOI   ScienceOn
20 E. R. Price, M. A. Horstmann, A. G. Wells, K. N. Weilbaecher, C. M. Takemoto, M. W. Landis, and D. E. Fisher,$\alpha$-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg Syndrome, J. Biol. Chem., 273, 33042 (1998).   DOI