Browse > Article

Anti-Aging Effect of Ligustrum japonicum Extract in the Human Fibroblast Cells  

Kim, Yun-Jeong (ACT Co., Ltd. R&D Center)
Lee, Yu-Ri (ACT Co., Ltd. R&D Center)
Cheon, Jong-Woo (ACT Co., Ltd. R&D Center)
Lee, Hyun-Sang (ACT Co., Ltd. R&D Center)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.36, no.4, 2010 , pp. 295-301 More about this Journal
Abstract
To develop wrinkle care cosmetic ingredients, various species of plant extracts were investigated. Accordingly, Ligustrum japonicum was selected as a candidate for developing cosmetic ingredient. By high performance liquid chromatography, 31.06 % of oleanolic acid and 8.92 % of ursolic acid which are well-known for anti-wrinkle effect were analyzed. The possibility of Ligustrum japonicum fruits extract (LJE) as a cosmetic ingredient was investigated using several biomarkers related to anti-aging, including anti-wrinkle, moisturizing and anti-inflammation. Procollagen type I and hyaluronan synthase-3 gene expression were increased by LJE in a concentration-dependent manner, whereas elastase activity and matrix metalloproteinase (MMP)-1, MMP-2 and cyclooxygenase-2 gene expression were inhibited. As the results LJE is applicable for a potential cosmetic ingredient focused on anti-aging effect.
Keywords
Ligustrum japonicum; procollagen type I; hyaluronan synthase-3; matrix metalloproteinases; cyclooxygenase-2;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 I. Gheretich, T. Lotti, G. Campanile, C. Grappone, and G. Dini, Hyaluronic acid in custaneous intrinsic aging, Int. J. Dermatol., 33, 119 (1994).   DOI   ScienceOn
2 K. Takadaa, T. Nakane, K. Masuda, and H. Ishii, Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF- ${\alpha}$ induced E-selectin expression by cultured umbilical vein endothelial cells, Phytomedicine, 17, 1114 (2010).   DOI   ScienceOn
3 J. Y. Seo, E. K. Kim, S. H. Lee, K. C. Park, K. H. Kim, H. C. Eun, and J. H. Chung, Enhanced expression of cylooxygenase-2 by UV in aged human skin in vivo, Mechanisms of Ageing and Development, 124, 903 (2003).   DOI   ScienceOn
4 J. A. Nichols and S. K. Katiyar, Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms, Arch. Dermatol. Res., 302(2), 71 (2009).
5 A. Hashem, K. Y. Jun, E. Y. Lee, S. Y. Lim, H. Y. Park Choo, and Y. J. Kwon, A rapid and sensitive screening system for human type I collagen with the aim of discoverying potent anti-aging or anti- fibrotic compounds, Mol. Cells OS, 26(6), 625 (2008).
6 W. M. Yang, H. M. Kim, M. S. Chang, W. S. Park, W. N. Kim, S. W. Kim, D. G. Choi, H. C. Lee, Y. K. Kim, and S. K. Park, Effects of ethanol extract of Nelumbo nucifera leaves on anti-oxidation and type I procollagen expression in CCD-986sk cells, The Korean Journal of Oriental Medical Prescripton, 14(2), 67 (2006).   과학기술학회마을
7 I. E. Collier, S. M. Wilhelm, and A. Z. Eisen, H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen, J. Biol. Chem., 263, 6579 (1988).
8 R. S. Komsa-Penkova, R. K. Rashap, and V. M. Yomtova, Advantages of orange-labelled collagen and gelatin as substrates for rapid collagenase activity measurement, J. Biochem. Biophys. Methods, 34(3), 237 (1997).   DOI   ScienceOn
9 M. O. Longas, C. S. Russell, and X. Y. He, Evidence for structural changes in dermatan sulfate and hyaluronic acid with aging, Carbohydr. Res., 159, 127 (1987).   DOI   ScienceOn
10 Z. D. Hea, H. Donga, H. X. Xua, W. C. Yea, H. D. Sunb, and P. H. Paul, Secoiridoid constituents from the fruits of Ligustrum lucidum, Phytochemistry, 56(4), 327 (2001).   DOI   ScienceOn
11 K. H. Jung and H. J. Kim, Development of an agar diffusion method to measure elastase inhibition activity using elastin-congo red, J. Microbiol. Biotechnol., 16(8), 1320 (2006).   과학기술학회마을
12 Y. S. Lee, D. Q. Jin, S. M. Beak, E. S. Lee, and J. A. Kim, Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes, European Journal of Pharmacology, 476, 173 (2003).   DOI   ScienceOn
13 E. S. Yang, R. H. Hong, and S. M. Kang, The effect of genistein on the proliferation and type I pN collagen synthesis in aged normal human fibroblasts, Kor. J. Microbiol. Biotechnol., 35(4), 316 (2007).   과학기술학회마을
14 J. Parrado, M. Bougria, A. Ayala, A. Castano, and A. Machado, Effects of aging on the various steps of protein synthesis fragmentation of elongation factors 2, Free Radical Biology & Medicine, 26(3-4), 362 (1999).   DOI   ScienceOn
15 M. Inui, M. Ooe, K. Fujii, H. Matsunaka, M. Yoshida, and M. Ichihashi, Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo, IOS Press, 32, 237 (2008).