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Protective Effect of Marine Natural Products against UVB-induced Damages in Human Skin Fibroblast via Antioxidant Mechanism  

Jang, Jung-Hee (Department of Pathology, College of Oriental Medicine, Daegu Hanny University)
Lee, Chan (Department of Pathology, College of Oriental Medicine, Daegu Hanny University)
Kim, Sang-Chan (Department of Herbal Prescription, College of Oriental Medicine, Daegu Hanny University)
Chung, Ji-Wook (Department of Herbal Medicinal Pharmacology, Daegu Hanny University)
Park, Chan-Ik (Department of Cosmeceutical Science, Daegu Hanny University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.36, no.1, 2010 , pp. 79-87 More about this Journal
Abstract
Ultraviolet is the one of the main environmental factors promoting aging process via increased intracellular generation of reactive oxygen species (ROS) and decreased expression of endogenous antioxidant enzymes and molecules. Therefore, in this study, we tried to search for natural skin-protective antioxidant materials from marine origins (Porphyra Thalli, Laminariae japonicae thallus, Ostreae Concha, Sargassum Thallus, Undaria thallus, Haliotidis Concha, Codium thalli, Syngnathoides biaculeatus, Hippocampus, Stichopus Stichopus, Thalli, Hizikia fusiforme thalli) which exhibit free radical scavenging activity and protect against UVB-induced cytotoxicity and oxidative cell death. Free radical scavenging activity was shown in order of Undaria thallus. Sargassum Thallus, Laminariae japonicae thallus, Hippocampus, Haliotidis Concha, Ostreae Concha, Syngnathoides biacuJeatus. In another experiment, UVB-induced cytotoxicity and cell death were effectively suppressed by treatment of Sargassum Thallus, Haliotidis Concha, Codium thalli, or Hippocampus water extract. Furthermore, UVB-induced cell death was mediated by intracellular accumulation or ROS, which was significantly inhibited by treatment with aforementioned extracts. The protective effect of these marine natural products seemed to be mediated by increased expression of antioxidant enzymes such as catalase, superoxide dismutase, and heme oxygenase-1. These results suggest that Sargassum Thallus, Haliotidis Concha, Codium thalli, and Hippocampus may have preventive and protective potentials as new functional cosmetics against oxidative stress-mediated skin damages and aging with antioxidant properties.
Keywords
ultraviolet; marine natural products; antioxidant; oxidative stress; skin fibroblast;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 O. Blokhina, E. Virolainen, and K. W. Fagerstedt, Antioxidnats, oxidative damage and oxygen deprivation stress: a review. Ann. Bot., 91. 179 (2003).   DOI   ScienceOn
2 L. E. Otterbein, M. P. Soares, K. Yamashita, and F. H. Bach, Heme oxygenase-1: unleashing the protective properties of heme, Trends Immunol.. 24, 449 (2003).   DOI   ScienceOn
3 M. Ichihashi, M. Ueda, A. Budiyanto, T. Bito, M. Oka, M. Fukunaga, K. Tsuru, and T. Horikawa, UV-induced skin damage, Toxicology, 189(1-2), 21 (2003).   DOI   ScienceOn
4 D. Kulms and T. Schwarz, Independent contribution of three different pathways to ultraviolet-B-induced apoptosis, Biochem. Pharmacol., 64(5-6), 837 (2002).   DOI   ScienceOn
5 M. J. Arends and A. H. Wyllie, Apoptosis: mechanisms and roles in pathology, Int. Rev. Exp. Pathol., 32, 223 (1991).
6 이홍금, 해양으로부터 기능성 화장품소재 개발동향, 보건사업기술동향, 42 (2001).
7 L. Rittie and G. J. Fisher, UV-light-induced signal cascades and skin aging, Ageing Research Reviews, 1(4), 705 (2002).   DOI   ScienceOn
8 H. S. Lee, H. A. Lee, C. O. Hong, S. Y. Yang, S. Y Hong, S. Y. Park, H. J. Lee, and K. W. Lee, Quantification of caffeic acid and rosmarinic acid and antioxidant activities of Hot-water extracts from leaves of Perilla frutescens, Kor. J Food Sci. Technol., 41(3), 302 (2009).   과학기술학회마을
9 W. Brand-Williams, M. E. Cuvelier, and C. Berset. Use of a free radical method to evaluate antioxidant activity, LWT - Food Sci. Technol, 28(1), 25 (1995).   DOI   ScienceOn
10 D. Harman, Free radical theory of aging: Alzheimer's disease pathogenesis, AGE, 18(3), 1574 (1995).
11 박수남, 피부노화와 활성산소, 서울산업대학교 논문집, 50, 329 (1999).
12 이혜영, 김귀정, 김영순, 이성내, 이성옥, 피부과학, 군자출판사, 서울 (2007).
13 M. Gilca, I. Stoian, W. Atanasiu, and B. Virgolici, The oxidative hypothesis of senescence. J. Prostgrad. Med., 53(3), 207 (2007).   DOI   ScienceOn
14 홍재기, 활성산소에 의한 피부노화와 항산화비타민의 효능에 대한 이론적 고찰, 대한피부미용학회지, 7(2), 51 (2009).
15 P. Brenneisen, H. Sies, and K. Scharffetter-Kochanek, Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events, Ann. N. Y Acad. Sci., 31, 973 (2002).
16 M. Yaar and B. A. Gilchrest, Photoageing: mechanism, prevention and therapy, Br. J Dermatol., 157(5), 874 (2007).   DOI   ScienceOn
17 S. W. Lim, H. C. Ryoo, and S. H. Lee, Understanding of skin aging and its prevention and care, JSBR, 4(1), 71 (2002).