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Tissue-cultured Gymnema sylvestre Leaf Extract Enhance Anti-adipogenic Effects through Inhibition of C/EBP-${\alpha}$ Expression and Lipid Droplet Accumulation  

Park, Chang-Min (R&D Center, Hankook Cosmetics Co., Ltd.)
Joung, Min-Seok (R&D Center, Hankook Cosmetics Co., Ltd.)
Choi, Jong-Wan (R&D Center, Hankook Cosmetics Co., Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.35, no.2, 2009 , pp. 111-116 More about this Journal
Abstract
Gymnema sylvestre, a traditional India medicine called a 'Gagaimogouip' in Korea, has been used to regulate sugar metabolism in patients with diabetes mellitus. First, we induced callus from Gymnema sylvestre leaf and mode extract from cultured callus. In this study, we investigated the anti-obesity effect of tissue-cultured Gymnema sylvestre leaf extract in 3T3-L1 cells. The tissue-cultured Gymnema sylvestre extract inhibited the cytoplasmic lipid accumulation as well as adipogenic differentiation of preadipocytes. The tissue-cultured Gymnema sylvestre extract inhibited insulin-induced predipocyte differentiation through the inhibition of expression of the early adipogenic transcription factor C/EBP-${\alpha}$ that regulate adipogenesis. These results indicate that tissue-cultured Gymnema sylvestre extract may be potential natural ingredient for slimming cosmetic products.
Keywords
Gymnema sylvestre; adipogenesis; C/EBP-${\alpha}$; anti-obesity; callus;
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Times Cited By KSCI : 1  (Citation Analysis)
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