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The Inhibition of UVA-induced Matrix Metalloproteinase-1 in Human Dermal Fibroblasts and the Improvement of Skin Elasticity by Cirsium setidens Extract  

Sim, Gwan-Sub (R&D Center, Hanbul Cosmetics Co. Ltd.)
Kim, Jin-Hwa (R&D Center, Hanbul Cosmetics Co. Ltd.)
Lee, Dong-Hwan (R&D Center, Hanbul Cosmetics Co. Ltd.)
Lee, Bum-Chun (Department of Biochemistry and Molecular Biology, Dalhousie University)
Lee, Geun-Soo (R&D Center, Hanbul Cosmetics Co. Ltd.)
Pyo, Hyeong-Bae (R&D Center, Hanbul Cosmetics Co. Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.33, no.3, 2007 , pp. 181-187 More about this Journal
Abstract
In this study, we measured the anti-oxidative activity of Cirsium setidens and investigated its effect on UVA-induced MMP-1 expression in human dermal fibroblats. And then we examined possible improvement in skin elasticity by topical treatment with fomular including Cirsium setidens extract. The ethanol extract of C. setidens showed free anion radical scavenging effect(87.47 % at 1 mg/mL) and superoxide anion radical scavenging effect(61.71 % at 1 mg/mL) in the xanthine/xanthine oxidase system, respectively. At the concentration of 100 ${\mu}g/mL$, C. setidens extract showed 95.54% inhibition on lipid peroxidation of linoleic acid. UVA-induced MMP-1 expression in human dermal fibroblasts was reduced to 54.69 % by treatment with 100 ${\mu}g/mL$ of C. setidens extract. A human clinical study, in which oil-in-water emulsion with C. setidens extract was topically applied, showed significant increase in skin elasticity. These results suggest that the C. setidens extract can be effective anti-aging ingredient for cosmetics applications.
Keywords
Cirsium setidens; antioxidation; MMPs; human dermal fibroblast; skin elasticity;
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