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A Study on the Whitening Effect of the Oriental Medicinal Herb Forsythia suspensa Fruit as a Cosmetic Ingredient  

Lee, Jung-Noh (Coreana Cosmetic Songpa R&D Center)
Park, Jea-Hee (Coreana Cosmetic Songpa R&D Center)
Kim, Sang-Woo (Coreana Cosmetic Songpa R&D Center)
Yoo, Young-Kyoug (Coreana Cosmetic Songpa R&D Center)
Lee, Ghang-Tai (Coreana Cosmetic Songpa R&D Center)
Lee, Kun-Kook (Coreana Cosmetic Songpa R&D Center)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.33, no.2, 2007 , pp. 79-86 More about this Journal
Abstract
The aim of this study was to investigate the inhibitory effects of Forsythia suspensa fruit extracts (FSfE) ($0.1{\sim}1.0%$) and their active component on melanogenesis. FSfE dose-dependently inhibited melanin synthesis (up to $63.1{\pm}3.1%$ at the concentration of 1.0%) without cell cytotoxicity. We purifed one active compound from FSfE and identified its structure. It was identified as 4-[(3,4-Dimethoxyphenyl)methyl)]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone (arctigenin) by $^1H-NMR,\;^{13}C-NMR$, and Mass analysis. Arctigenin also inhibited melanin synthesis in a dose dependent manner (up to $52.7{\pm}3.1%$ at the concentration of $3.0{\mu}g/mL$). In order to verify the whitening activity of the cream containing 3% FSfE, we performed the clinical test with twenty five female volunteers for 8 weeks. Bioengineering analyses and visual assessment by doctors at the initial time point and 8 weeks after applications showed that cream containing FSfE have significant whiteining effect (paired t-test). From the results, we conclude that the FSfE can be used as a useful whitening agent.
Keywords
uhiteing agent; Forsythia suspensa fruit extracts (FSfE); melanogenis; arctigenin;
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