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Studies on the Anti-inflammatory Activity of Paulownia coreana Uyeki Leaf Extract  

Kim, Nam-Kyoung (Radiant Inc., Bioindustry Innovation Center, Hi-Tech Venture Town)
Kim, Mi-Hwa (Radiant Inc., Bioindustry Innovation Center, Hi-Tech Venture Town)
Yoon, Chang-Soon (Radiant Inc., Bioindustry Innovation Center, Hi-Tech Venture Town)
Choi, Shin-Wook (Radiant Inc., Bioindustry Innovation Center, Hi-Tech Venture Town)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.32, no.4, 2006 , pp. 241-247 More about this Journal
Abstract
This work was carried out to investigate the anti-inflammatory effects of Paulownia coreana Uyeki on abirritant, atopy and acne skin. Paulownia coreana Uyeki has been used as a traditional medicine having anti-febrile, anti-inflammation effect in Korea, Paulownia coreana Uyeki loaves were extracted with 70% EtOH. Its superoxide anion radical scavenging activity and inhibitory effect on LPS-induced NO production were examined. The extract inhibitied the generation of NO and $PGE_2$ induced by LPS in the macrophage cell line (Raw 264.7). Consistent with the inhibitory effects on No and $PGE_2$ generation, the extract inhibited expression of iNOS and COX-2. In further study, it was found that the extract prevented $IkB-{\alpha}$ degradation, as demonstrated by western blot analysis of $IkB-{\alpha}$ protein level. However, the extract treatment did not affect cell viability at $100{\mu}g/mL$ concentration in both human skin fibroblast and Raw 264.7 cells in vitro. Thus, the present study suggests that Paulownia coreana Uyeki leaves extract have significant anti-inflammatory activity and potential as an anti-irritation material.
Keywords
anti-inflammatory effect; superoxide anion radical scavenging activity; Paulownia coreana Uyeki; $IkB-{\alpha}$;
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