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Effects of Emulsion Containing the Specific Antibodies against staphylococcus aureus and Staphylococcal Toxins on Atopic Dermatitis  

Kim, Mi-Rye (Life Sciences Research Center, Danbiotech. Inc.)
Yang, Si-Yong (Life Sciences Research Center, Danbiotech. Inc.)
Han, Tae-Young (Department of Dermatology, Chung-Ang University Hospital)
Seo, Seong-Jun (Department of Dermatology, Chung-Ang University Hospital)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.32, no.4, 2006 , pp. 233-239 More about this Journal
Abstract
This study was carried out for the evaluation of the effects of emulsion containing the specific antibodies against S. aureus that secreted staphylococcal toxins in atopy dermatitis (AD). The emulsion was formulated to have basic moisturizing effect and the function to inhibit S. aureus colonization and Staphylococcal toxins. The results were as follows; 1. In 19 subjects, 14 subjects (73.7%) showed improvement in SCORAD the mean SCORAD score was improved by 21.87% at week 4 compared to pre-application (p < 0.05). 2. In 17 subjects with severe lesions, 14 subjects(82.35%) showed improvement in SCORAD; the mean SCORAD score was improved by 25.11% at week 4 compared to pre-application (p < 0.05). 3. In 19 subjects, 15 subjects (79%) showed improvement in TEWL; the mean TEWL was improved by 24.32% at week 4 compared to pre-application (p < 0.05). 4. In 17 subjects with severe lesions, 14 subjects (82.35%) showed improvement in TEWL; the mean TEWL was improved by 25.47% at week 4 compared to pre-application (p < 0.05). 5. In 19 subjects, 15 subjects (79%) showed improvement in keratin capacitance; the mean keratin capacitance was improved by 25.01% at week 4 compared to pre-application (P < 0.05). 6. In 17 subjects with severe lesions, 13 subjects (76.47%) showed improvement in keratin capacitance; the mean keratin capacitance was improved by 20.82% at week 4 compared to pre-application (p < 0.05). Based on above-described results, emulsion containing the specific antibodies against S. aureus that secreted staphylococcal toxins is considered to be helpful in the improvement of atopic dermatitis.
Keywords
atopic dermatitis; SCORAD; TEWL; capacitance; staphylococcus aureus;
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