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Sprouted Black Rice Oligopeptide Induces Expression of Hyaluronan Synthase in HaCaT Keratinocytes and Improves Skin Elasticity  

Sim, Gwan-Sub (R&D Center, Hanbul Cosmetics Co. Ltd.)
Lee, Dong-Hwan (R&D Center, Hanbul Cosmetics Co. Ltd.)
Kim, Jin-Hwa (R&D Center, Hanbul Cosmetics Co. Ltd.)
Lee, Bum-Chun (R&D Center, Hanbul Cosmetics Co. Ltd.)
Ahn, Sung-Kwan (Division of Chemical and Biological Engineering, Konkuk University)
Choe, Tae-Boo (Division of Chemical and Biological Engineering, Konkuk University)
Pyo, Hyeong-Bae (R&D Center, Hanbul Cosmetics Co. Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.32, no.1, 2006 , pp. 7-15 More about this Journal
Abstract
In this study, the effect of oligopeptide ($Oligosproutin^{(R)}$) from sprouted black rice was evaluated for possible improvement in skin elasticity. We examined the changes in gene expression on oligopeptide-treated HaCaT cells using DNA microarray analysis. As a result, oligopeptide treatment showed a differential expression ratio of more than 2-fold : 745 genes were activated and 1011 genes were repressed. One of the most interesting findings is a 2-fold increase in hyaluronan synthase 2 (HAS 2) gene expression by oligopeptide. We also found that oligopeptide increased cell proliferation, HAS2 mRNA expression and intracellular ROS scavenging activity in HaCaT cells. A human clinical study which oil-in-water emulsion with oligopeptide was topically applied showed significant increase in skin elasticity. These results suggest that the sprouted black rice oligopeptide ($Oligosproutin^{(R)}$) can be effective anti-aging ingredient for cosmetics.
Keywords
sprouted black rice; microarray; oligopeptide; hyaluronan synthase; elasticity;
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