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The Effects and Mechanisms of Glycolic Acid on the UV-induced Skin Cell Proliferation  

Hong, Jin-Tae (College of Pharmacy, Chungbuk National University)
Lee, Hwa-Jeong (College of Pharmacy, Chungbuk National University)
Lee, Chung-Woo (College of Pharmacy, Chungbuk National University)
Ahn, Kwang-Soo (Korea Food and Drug Agency)
Yun, Yeo-Pyo (College of Pharmacy, Chungbuk National University)
Pyo, Heung-Bae (R&D Center, Hanbul Cosmetics Co.)
Cho, Chan-Hwi (Department of Beauty Care, Youngdong University)
Hong, Ki-Young (School of English Language and Literature, Hannam University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.31, no.3, 2005 , pp. 219-236 More about this Journal
Abstract
Glycolic acid, an alpha-hydroxy acid derived from fruit and milk sugars, has been commonly used as a cosmetic ingredient since it was known to have photo-protective, anti-inflammatory effects, and anti-oxidant effect in UV-irradiated skin. However, little has been know about the functional role of glycolic acid on UV-induced skin cell proliferation. It was previously found that glycolic acid inhibited UV-induced skin tumor development in hairless mouse. As a possible mechanism of glycolic acid on the UV-induced skin tumor development, the ability of glycolic acid to inhibit the UVB-induced cell growth and possible mechanisms were investigated. Glycolic acid treatment attenuated the UV-induced cell proliferation and apoptotic cell death in the skin. In vitro study, glycolic acid inhibited the UVB-induced cell growth and apoptotic death through inhibiting caspase-3 activity. These results suggest that glycolic acid may exert the Inhibitory effect on the UVB-induced skin tumor development by regulating cell growth and apoptotic cell death.
Keywords
glycolic acid; UV; cell proliferation; apoptosis;
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